Expression of human telomerase subunit genes in primary lung cancer and its clinical significance Mitsuyuki Arinaga, MD, Shigeki Shimizu, MD, Kunihiko.

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Expression of human telomerase subunit genes in primary lung cancer and its clinical significance Mitsuyuki Arinaga, MD, Shigeki Shimizu, MD, Kunihiko Gotoh, MD, Nobuhiro Haruki, MD, Takao Takahashi, MD, Takashi Takahashi, MD, Tetsuya Mitsudomi, MD The Annals of Thoracic Surgery Volume 70, Issue 2, Pages 401-405 (August 2000) DOI: 10.1016/S0003-4975(00)01454-5

Fig 1 Results of reverse transcription-polymerase chain reaction analysis of telomerase subunits and the TRAP assay for paired lung cancer and adjacent non-neoplastic lung tissues. (AD = adenocarcinoma; CS = carcinosarcoma; GAPDH = glyceraldehyde 3-phosphate dehydrogenase; hTERC = human telomerase RNA component; hTERT = human telomerase catalytic subunit; N = non-neoplastic adjacent lung tissue; SQ = squamous cell carcinoma; T = tumor tissue; TEP1 = telomerase-associated protein; TRAP = telomeric repeat amplification protocol.) The Annals of Thoracic Surgery 2000 70, 401-405DOI: (10.1016/S0003-4975(00)01454-5)

Fig 2 Survival curves for patients with lung cancer stratified by expression of human telomerase catalytic subunit (hTERT) (p = 0.64). The solid line is for patients with hTERT-positive tumors (n = 82) and the hatched line is for those with hTERT-negative tumors (n = 10). The Annals of Thoracic Surgery 2000 70, 401-405DOI: (10.1016/S0003-4975(00)01454-5)