Cyclooxygenase-2 inhibition decreases primary and metastatic tumor burden in a murine model of orthotopic lung adenocarcinoma Costanzo A. DiPerna, MD,

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Presentation transcript:

Cyclooxygenase-2 inhibition decreases primary and metastatic tumor burden in a murine model of orthotopic lung adenocarcinoma Costanzo A. DiPerna, MD, Robert D Bart, MD, Eric M Sievers, MD, Yanling Ma, MD, Vaughn A Starnes, MD, Ross M Bremner, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 126, Issue 4, Pages 1129-1133 (October 2003) DOI: 10.1016/S0022-5223(03)00790-6

Figure 1 Lymph nodes identified on gross examination (percent of mice with mediastinal lymph nodes) are compared between celecoxib-treated and untreated mice at each respective week. Weeks 3 and 4 were significant for differences between treated and untreated groups (P < .0001; 2-sided Fisher exact test). The Journal of Thoracic and Cardiovascular Surgery 2003 126, 1129-1133DOI: (10.1016/S0022-5223(03)00790-6)

Figure 2 Primary tumor volumes (mean ± SD) are compared between celecoxib-treated and untreated mice at each respective week. Weeks 3 and 4 were significant for differences between treated and untreated groups (P < .0001; Mann-Whitney U test). The Journal of Thoracic and Cardiovascular Surgery 2003 126, 1129-1133DOI: (10.1016/S0022-5223(03)00790-6)

Figure 3 Three-week necropsy specimens consisting of left upper lung lobe, heart, and mediastinum with arrows indicating tumor in celecoxib-treated (A) and untreated (B) mice. The Journal of Thoracic and Cardiovascular Surgery 2003 126, 1129-1133DOI: (10.1016/S0022-5223(03)00790-6)