Chris M. Bacon, PhD, Sarah J. Wilkinson, MRes, Gavin P

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Presentation transcript:

Epstein-Barr virus–independent diffuse large B-cell lymphoma in DNA ligase 4 deficiency Chris M. Bacon, PhD, Sarah J. Wilkinson, MRes, Gavin P. Spickett, PhD, Dawn Barge, PhD, Helen H. Lucraft, MD, Graham Jackson, MD, Vikki Rand, PhD, Andrew R. Gennery, MD Journal of Allergy and Clinical Immunology Volume 131, Issue 4, Pages 1237-1239.e1 (April 2013) DOI: 10.1016/j.jaci.2012.10.027 Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Diffuse large B-cell lymphoma, not otherwise specified. Upper left: Diffuse large atypical lymphoid cells with a high mitotic rate and abundant single cell death (hematoxylin and eosin stain). Remaining panels: Immunohistochemical staining showing neoplastic cells expressing CD20, CD10, and CGET1, consistent with a germinal center B-cell phenotype, and IgD but not IgM. The Ki67-positive proliferative fraction was greater than 95% of neoplastic cells. Journal of Allergy and Clinical Immunology 2013 131, 1237-1239.e1DOI: (10.1016/j.jaci.2012.10.027) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions