Outcomes of ER stress Outcomes of ER stress Perturbation of ER homeostasis or ‘ER stress’ (blue), is ameliorated by the triggering of signalling cascades.

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Presentation transcript:

Outcomes of ER stress Outcomes of ER stress Perturbation of ER homeostasis or ‘ER stress’ (blue), is ameliorated by the triggering of signalling cascades (yellow), which in turn engage downstream effector mechanisms (green). Generally speaking, these mechanisms restore homeostasis. This review will discuss these pathways and mechanisms, with particular focus on autophagy as a potential effector and, in further detail, selective autophagic degradation of ER luminal contents or ER (ER-quality control (ERQC)-autophagy, ER-associated degradation (ERAD)-II and ER-phagy). Matthew Smith, and Simon Wilkinson Essays Biochem. 2017;61:625-635 ©2017 by Portland Press Ltd