Expert Perspectives in the Recognition and Management of Lennox-Gastaut Syndrome
This program will include a discussion of off-label treatment and investigational agents not approved by the FDA for use in the United States.
Introduction to LGS
Epidemiology of LGS
Epidemiology of LGS (cont)
Symptom Presentation
Atonic-Clonic Seizure
Tonic Seizure
Tonic Seizure Symptomatic Generalized Epilepsy
LGS Triad
EEG Findings in LGS
Differential Diagnosis
Evaluation
EEG Characteristics
Treatment Goals
Treatment Options
Pharmacologic Treatment
FDA-Approved Pharmacologic Treatment for LGS*
Felbamate: Adjunctive Therapy
Lamotrigine: Adjunctive Therapy
Topiramate: Adjunctive Therapy
Rufinamide: Adjunctive Therapy
Clobazam: Adjunctive Therapy
Challenges in the Treatment of LGS
Ketogenic Diet
Corpus Callosotomy
Vagus Nerve Stimulation
Investigational Treatment: Perampanel
Investigational Treatment: Cannabidiol
Comorbidities in LGS
Transition to Care by an Adult Neurologist
Conclusions
Abbreviations