Telomere Length and Recurrence Risk after Curative Resection in Patients with Early- Stage Non–Small-Cell Lung Cancer: A Prospective Cohort Study Eric.

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Presentation transcript:

Telomere Length and Recurrence Risk after Curative Resection in Patients with Early- Stage Non–Small-Cell Lung Cancer: A Prospective Cohort Study Eric S. Kim, MD, Yuanqing Ye, PhD, Ara A. Vaporciyan, MD, Jinliang Xing, MD, PhD, Maosheng Huang, MD, Jian Gu, PhD, Jack A. Roth, MD, Scott M. Lippman, MD, Xifeng Wu, MD, PhD Journal of Thoracic Oncology Volume 10, Issue 2, Pages 302-308 (February 2015) DOI: 10.1097/JTO.0000000000000398 Copyright © 2015 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Association of telomere length with sex, histology, and recurrence. Women had longer RTL compared with men, and the patients with adenocarcinoma demonstrated longer RTL compared with those of other histologic types. Patients who developed recurrence had significantly longer mean RTL compared with those without recurrence. RTL, relative telomere length. Journal of Thoracic Oncology 2015 10, 302-308DOI: (10.1097/JTO.0000000000000398) Copyright © 2015 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 A–C, Kaplan–Meier estimates of recurrence in NSCLC patients with long versus short RTL following curative resection. In women with adenocarcinoma (D), those with longer telomeres had significantly longer time to recurrence. NSCLC, non–small-cell lung cancer; RTL, relative telomere length. Journal of Thoracic Oncology 2015 10, 302-308DOI: (10.1097/JTO.0000000000000398) Copyright © 2015 International Association for the Study of Lung Cancer Terms and Conditions