Modulation of Cell–Fibronectin Matrix Interactions during Tissue Repair  Kim S. Midwood, Yong Mao, Henry C. Hsia, Leyla V. Valenick, Jean E. Schwarzbauer  Journal of Investigative Dermatology Symposium Proceedings  Volume 11, Issue 1, Pages 73-78 (September 2006) DOI: 10.1038/sj.jidsymp.5650005 Copyright © 2006 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Modulation of cell interactions with fibronectin matrices. (a) Adhesion, spreading, and contraction mediated by α5β1 integrin and syndecan-4 are reduced with deposition of tenascin-C into a 3D fibrin–fibronectin matrix (left). By blocking syndecan-4 binding to fibronectin, tenascin-C downregulates signaling through FAK and Rho GTPase. Cells expressing α4β1 integrin show reduced adhesion and are unable to spread on or contract a 3D fibrin–fibronectin matrix when the fibronectin is intact (right). (b) Conditions that support cell adhesion, spreading, and matrix contraction include cells that express α5β1 and syndecan-4 interacting with a 3D fibrin–fibronectin matrix (left) or α4β1-expressing cells interacting with 3D fibrin-fragmented fibronectin matrix (right). Dashed arrows indicate multiple steps between receptors and cell activities. Journal of Investigative Dermatology Symposium Proceedings 2006 11, 73-78DOI: (10.1038/sj.jidsymp.5650005) Copyright © 2006 The Society for Investigative Dermatology, Inc Terms and Conditions