Ji Zhang, MD, Robert D Furukawa, BSc, Stephen E Fremes, MD, Donald A

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Volume 33, Issue 5, Pages (May 1958)

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Presentation transcript:

Effects of Butanedione Monoxime and Temperature on Prolonged Cardiac Storage Ji Zhang, MD, Robert D Furukawa, BSc, Stephen E Fremes, MD, Donald A.G Mickle, MD, Richard D Weisel, MD The Annals of Thoracic Surgery Volume 63, Issue 2, Pages 388-394 (February 1997) DOI: 10.1016/S0003-4975(96)00894-6

Fig. 1 The recovery of developed pressure (mean ± standard deviation, n = 6/group) was enhanced in the BDM groups in comparision with unmodified UWS hearts. Zero to 8°C were the preferred storage temperatures in the BDM group and 4°C with unmodified UWS. (BDM = University of Wisconsin solution supplemented with 2,3-butanedione monoxime 10 mmol/L and calcium 0.1 mmol/L; UWS = University of Wisconsin solution.) The Annals of Thoracic Surgery 1997 63, 388-394DOI: (10.1016/S0003-4975(96)00894-6)

Fig. 2 Representative individual left ventricular end-diastolic pressure–volume curves are depicted before storage (Pre-storage) and after 12 hours of storage at 4°C (Post-storage). The upper panel was obtained using University of Wisconsin solution supplemented with 10 mmol/L 2,3-butanedione monoxime and 0.1 mmol/L calcium (BDM), and the lower panel was acquired using unmodified University of Wisconsin solution (UWS). The left ventricular end-diastolic pressure–volume curve was shifted upward and to the left (increased slope and decreased x-intercept) with unmodified University of Wisconsin solution yet minimally affected with BDM. The Annals of Thoracic Surgery 1997 63, 388-394DOI: (10.1016/S0003-4975(96)00894-6)

Fig. 3 Diastolic volume at a left ventricular end-diastolic pressure of 20 mm Hg is presented as a percentage of the prestorage value (mean ± standard deviation, n = 6/group). Recovery of diastolic function was improved with University of Wisconsin solution (UWS) supplemented with 10 mmol/L 2,3-butanedione monoxime and 0.1 mmol/L calcium (BDM) for temperatures 8°C or less. The optimal storage temperature was 0° to 8°C with BDM and 4° to 8°C with unmodified University of Wisconsin solution. The Annals of Thoracic Surgery 1997 63, 388-394DOI: (10.1016/S0003-4975(96)00894-6)

Fig. 4 Poststorage coronary flow (mean ± standard deviation, n = 6/group) was greater with University of Wisconsin solution (UWS) supplemented with 10 mmol/L 2,3-butanedione monoxime and 0.1 mmol/L calcium (BDM) versus unmodified University of Wisconsin solution (UWS) for storage at 0°, 4°, and 8°C. Results for the BDM groups were significantly greater at 0° to 8°C than at 12° to 16°C. There was no significant temperature effect detected in the UWS hearts. The Annals of Thoracic Surgery 1997 63, 388-394DOI: (10.1016/S0003-4975(96)00894-6)