Bioactive Cell-Penetrating Peptides: Kill Two Birds with One Stone

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Bioactive Cell-Penetrating Peptides: Kill Two Birds with One Stone Gilles Divita Chemistry & Biology Volume 17, Issue 7, Pages 679-680 (July 2010) DOI: 10.1016/j.chembiol.2010.07.002 Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 1 Design and Potency of Bioactive Cell-Penetrating Peptides Cell-penetrating peptide (CPP) can be linked to inhibitor and targeting motif (TM) or computer-based optimized using (QSAR) (1) to a single sequence containing bioactive cell-penetrating sequence (BCPP) that will improve cellular uptake (3), endosomal release (4), and biological response (6), and a targeting motif (TM) that will favor either cell targeting (2) or cellular trafficking (5). Chemistry & Biology 2010 17, 679-680DOI: (10.1016/j.chembiol.2010.07.002) Copyright © 2010 Elsevier Ltd Terms and Conditions