Role of the endometrial tripod interleukin-18, -15, and -12 in inadequate uterine receptivity in patients with a history of repeated in vitro fertilization–embryo.

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Presentation transcript:

Role of the endometrial tripod interleukin-18, -15, and -12 in inadequate uterine receptivity in patients with a history of repeated in vitro fertilization–embryo transfer failure Nathalie Lédée-Bataille, M.D., Ph.D, Karen Bonnet-Chea, M.D, Ms.C., Ghada Hosny, M.D., Ms.C., Sylvie Dubanchet, René Frydman, M.D., Gérard Chaouat, M.D., Ph.D. Fertility and Sterility Volume 83, Issue 3, Pages 598-605 (March 2005) DOI: 10.1016/j.fertnstert.2004.11.021 Copyright © 2005 American Society for Reproductive Medicine Terms and Conditions

FIGURE 1 Differences between fertile patients and patients in the implantation failure group (A) on the uterine artery pulsatility index and (B) on the number of CD56 bright cells/field. Fertility and Sterility 2005 83, 598-605DOI: (10.1016/j.fertnstert.2004.11.021) Copyright © 2005 American Society for Reproductive Medicine Terms and Conditions

FIGURE 2 Correlation between (A) the mRNA cytokine ratio and the vascular status (uterine (ut.) artery pulsatility index) and (B) the mRNA cytokine ratio and the count of uterine natural killer (uNK) cells. Fertility and Sterility 2005 83, 598-605DOI: (10.1016/j.fertnstert.2004.11.021) Copyright © 2005 American Society for Reproductive Medicine Terms and Conditions

FIGURE 3 Anti-IL-18 immunostaining. The anti-IL18 staining was clearly located on the smooth muscle cells surrounding the spiral arteries (SA) by immunochemistry. Fertility and Sterility 2005 83, 598-605DOI: (10.1016/j.fertnstert.2004.11.021) Copyright © 2005 American Society for Reproductive Medicine Terms and Conditions