Venous endothelial function in postmenopausal women who are receiving long-term estrogen and progestagen therapy Concepción Ceballos, Constantino Ribes,

Slides:

Advertisements

Similar presentations

Hormone Replacement Therapy in Postmenopausal Women: Urinary N-Telopeptide of Type I Collagen Monitors Therapeutic Effect and Predicts Response of Bone.

Advertisements

Copyright © 2015 by the American Osteopathic Association.

Clinically significant and sustained weight loss is achievable in obese women with polycystic ovary syndrome followed in a regular medical practice Lysanne.

Endometrial bleeding in hormone replacement therapy users: preliminary findings regarding the role of matrix metalloproteinase 9 (MMP-9) and tissue inhibitors.

Philip M. Sarrel, M. D. , Shannon D. Sullivan, M. D. , Ph. D

Diagnostic Options for Assessment of Postmenopausal Bleeding

Improved vessel preservation after 4 days of cold storage: Experimental study in rat arteries Birgit Zatschler, Peter Dieterich, PhD, Bianca Müller,

Relief of vasomotor symptoms and vaginal atrophy with lower doses of conjugated equine estrogens and medroxyprogesterone acetate Wulf H Utian, M.D.,

Divergent effects of a combined hormonal oral contraceptive on insulin sensitivity in lean versus obese women Kai I. Cheang, Pharm.D., M.S., Paulina.

Volume 68, Issue 2, Pages (August 2005)

Volume 119, Issue 2, Pages (August 2000)

Circulating microparticles from patients with valvular heart disease and cardiac surgery inhibit endothelium-dependent vasodilation Li Fu, MD, Xiao-Xia.

Edward A. Black, Tomasz J. Guzik, MD, Nick E. J

Endothelial nitric oxide synthase activity involves in the protective effect of ascorbic acid against penicillin-induced epileptiform activity Mehmet.

Hormones and bones The Lancet Volume 349, Pages S20-S23 (March 1997)

Thomas V Bilfinger, MD, George B Stefano, PhD

Laryngeal cytological aspects in women with surgically induced menopause who were treated with transdermal estrogen replacement therapy Salvatore Caruso,

Monitoring of hormone replacement therapy in postmenopausal women by transvaginal sonography and color flow doppler: study in different phases of sequential.

Marilyn J. Cipolla, MS, Christian T. Harker, PhD, John M. Porter, MD

Two-year prospective, randomized trial comparing an innovative twice-a-week progestin regimen with a continuous combined regimen as postmenopausal hormone.

A randomized comparative study of the effects of oral and topical estrogen therapy on the lower urinary tract of hysterectomized postmenopausal women

Mammographic breast density, hormones, and growth factors during continuous combined hormone therapy Peter Conner, M.D., Gunilla Svane, M.D., Ph.D.,

A randomized, controlled clinical trial comparing the effects of aromatase inhibitor (letrozole) and gonadotropin-releasing hormone agonist (triptorelin)

Goserelin Acetate (Zoladex)∗with or without Hormone Replacement Therapy for the Treatment of Endometriosis Kamran S Moghissi, M.D., William D Schlaff,

Effect of the oxytocin antagonist antocin and agonist decomoton on baboon luteal cell production and release of progesterone M. Yusoff Dawood, M.D.,

Mukut Sharma, Ellen T. Mccarthy, Virginia J. Savin, Elias A. Lianos

Persistent osteopenia in ballet dancers with amenorrhea and delayed menarche despite hormone therapy: a longitudinal study Michelle P Warren, MD, Jeanne.

Orhan Bukulmez, M. D. , Qin Li, M. S. , Bruce R. Carr, M. D

Failure of the GnRH antagonist ganirelix to block the positive feedback effect of exogenous estrogen in normal women Ioannis E. Messinis, M.D., Ph.D.,

Oral dehydroepiandrosterone supplementation modulates spontaneous and growth hormone-releasing hormone-induced growth hormone and insulin-like growth.

Hao G. Nguyen, MD, PhD, Amit Korach, MD, Chey Collura, MA, Benjamin R

Effect of short-term hormone therapy on oxidative stress and endothelial function in African American and Caucasian postmenopausal women Raymond W Ke,

Hypomagnesemia Inhibits Nitric Oxide Release From Coronary Endothelium: Protective Role of Magnesium Infusion After Cardiac Operations1 Paul J. Pearson,

Subtle progesterone rise on the day of human chorionic gonadotropin administration is associated with lower live birth rates in women undergoing assisted.

Association of a single dose of gonadotropin-releasing hormone antagonist with nitric oxide and embryo quality in in vitro fertilization cycles Tsung-Hsien.

Vaginal rings delivering progesterone and estradiol may be a new method of hormone replacement therapy Takeshi Maruo, M.D., Daniel R Mishell, M.D., Avraham.

Gonadotropin-releasing hormone agonist plus “add-back” hormone replacement therapy for treatment of endometriosis: a prospective, randomized, placebo-controlled,

Robert F. Casper, M.D. Fertility and Sterility

Role of glucocorticoid receptor in the inhibitory effect of medroxyprogesterone acetate on the estrogen-induced endothelial nitric oxide synthase phosphorylation.

Thrombolysis for experimental deep venous thrombosis maintains valvular competence and vasoreactivity Jeffrey M. Rhodes, MD, Jae-Sung Cho, MD, Peter.

From partner's desk to iPad

Low-dose hormone therapy and carbohydrate metabolism

Akanksha Mehta, M.D., Darius A. Paduch, M.D., Ph.D.

Difference in acetylcholine-induced nitric oxide release of arterial and venous grafts in patients after coronary bypass operations Hiroaki Nishioka,

Volume 62, Issue 4, Pages (October 2002)

Ettore Cicinelli, M. D. , Louis J Ignarro, M. D. , Pietro Galantino, M

Effects of nonoral estradiol–micronized progesterone or low-dose oral estradiol– drospirenone therapy on metabolic variables and markers of endothelial.

Paulo R. B. Evora, MD, PhD, Paul J

Estrogen therapy increases plasma concentrations of nitric oxide metabolites in postmenopausal women but increases flow-mediated vasodilation only in.

Cigarette smoke inhibits endometrial epithelial cell proliferation through a nitric oxide– mediated pathway Omid Khorram, M.D., Ph.D., Guang Han, M.D.,

Regulation of assisted reproductive technologies in the United States

Naloxone decreases insulin secretion in hyperinsulinemic postmenopausal women and may positively affect hormone replacement therapy Francesco Cucinelli,

Effects of treatment with testosterone alone or in combination with estrogen on insulin sensitivity in postmenopausal women Hong Zang, M.D., Kjell Carlström,

Volume 62, Pages S36-S41 (December 2002)

Effects of patch or gel estrogen therapies on auditory brainstem response in surgically postmenopausal women: a prospective, randomized study Salvatore.

Effect of gonadotropin-releasing-hormone-induced hypogonadism on insulin action as assessed by euglycemic clamp studies in men Subodhsingh Chauhan, M.D.,

Paolo Moghetti, M.D. Fertility and Sterility

Variability of serum estrogens among postmenopausal women treated with the same transdermal estrogen therapy and the effect on androgens and sex hormone.

A critique of the Women’s Health Initiative hormone therapy study

George Christodoulakos, M. D. , Irene Lambrinoudaki, M. D

Low-dose conjugated equine estrogens elevate circulating neurotransmitters and improve the psychological well-being of menopausal women Arturo Zárate,

Effects of a single dose of oral estrogen on left ventricular diastolic function in hypertensive postmenopausal women with diastolic dysfunction Ali.

Medroxyprogesterone acetate does not antagonize estrogen-induced increases in endothelium-dependent vasodilation: potential clinical implications Hillary.

Effects of FK506 in rat and human resistance arteries

Volume 61, Issue 4, Pages (April 2002)

Thomas M Price, M.D., Susan Allen, R.N., G.Vernon Pegram, M.D.

Microdose gonadotropin-releasing hormone agonist in the absence of exogenous gonadotropins is not sufficient to induce multiple follicle development

Estrogen improves endothelial function

Panagiotis Kougias, MD, Hong Chai, MD, PhD, Peter H. Lin, MD, Alan B

Low-dose human chorionic gonadotropin therapy can improve sensitivity to exogenous follicle-stimulating hormone in patients with secondary amenorrhea

Presentation transcript:

Venous endothelial function in postmenopausal women who are receiving long-term estrogen and progestagen therapy Concepción Ceballos, Constantino Ribes, José A Amado, M.D., Josefina Pérez, M.D., Marı́a Teresa Garcı́a Unzueta, José R de Berrazueta, M.D. Fertility and Sterility Volume 74, Issue 2, Pages 268-273 (August 2000) DOI: 10.1016/S0015-0282(00)00627-0

Figure 1 (A), Effect of nitric oxide (NO)–dependent relaxation of the dorsal hand vein induced by bradykinin, given at 2 (Bk 2), 4 (Bk 4), and 8 (Bk 8) pmol/min in group A. Values were measured at baseline (“Basal”); at 6 months, during which postmenopausal women in group A did not receive hormone replacement therapy (HRT); and 12 months, after women in group A had received HRT for 6 months. The NO dependent relaxation improved significantly (∗∗P=.002). (B), Effect of NO-dependent relaxation of the dorsal hand vein induced by bradykinin at the above doses in group B. Values were measured at baseline (“Basal”); at 6 months, during which postmenopausal women in group B had received HRT; and at 12 months, after women in group B had discontinued HRT for 6 months. At 6 months, significant improvement in NO-dependent relaxation was seen (∗∗∗P<.0001), but at 12 months, this effect was lost. Ceballos. Venous endothelial function in HRT. Fertil Steril 2000. Fertility and Sterility 2000 74, 268-273DOI: (10.1016/S0015-0282(00)00627-0)

Figure 1 (A), Effect of nitric oxide (NO)–dependent relaxation of the dorsal hand vein induced by bradykinin, given at 2 (Bk 2), 4 (Bk 4), and 8 (Bk 8) pmol/min in group A. Values were measured at baseline (“Basal”); at 6 months, during which postmenopausal women in group A did not receive hormone replacement therapy (HRT); and 12 months, after women in group A had received HRT for 6 months. The NO dependent relaxation improved significantly (∗∗P=.002). (B), Effect of NO-dependent relaxation of the dorsal hand vein induced by bradykinin at the above doses in group B. Values were measured at baseline (“Basal”); at 6 months, during which postmenopausal women in group B had received HRT; and at 12 months, after women in group B had discontinued HRT for 6 months. At 6 months, significant improvement in NO-dependent relaxation was seen (∗∗∗P<.0001), but at 12 months, this effect was lost. Ceballos. Venous endothelial function in HRT. Fertil Steril 2000. Fertility and Sterility 2000 74, 268-273DOI: (10.1016/S0015-0282(00)00627-0)

Figure 2 Comparative inhibition of NO-dependent relaxation of the dorsal hand vein by administration of NG-monomethyl l-arginine (l-NMMA) in postmenopausal women. Women in group A had not received hormone replacement therapy at 6 months, whereas women in group B had been receiving it from baseline to that time point. The maximum relaxation achieved with bradykinin (Bk) was suppressed by the effect of l-NMMA, the competitive inhibitor of the nitric oxide precursor l-arginine. This finding indicates that bradykinin promotes relaxation through the release of endothelial nitric oxide. Ceballos. Venous endothelial function in HRT. Fertil Steril 2000. Fertility and Sterility 2000 74, 268-273DOI: (10.1016/S0015-0282(00)00627-0)

Figure 3 Exogenous nitric oxide–independent relaxation of the dorsal hand vein in postmenopausal women induced by sodium nitroprusside (SNP). The effect of sodium nitroprusside was similar in group A (women who did not receive hormone replacement therapy in the 6 months after the baseline visit) and group B (women who received hormone replacement therapy in the 6 months after the baseline visit). Ceballos. Venous endothelial function in HRT. Fertil Steril 2000. Fertility and Sterility 2000 74, 268-273DOI: (10.1016/S0015-0282(00)00627-0)