T Cell Repertoire Development in XSCID Dogs Following Nonconditioned Allogeneic Bone Marrow Transplantation William Vernau, Brian J. Hartnett, Douglas.

Slides:

Advertisements

Similar presentations

Evidence of B Cell Immune Responses to Acute Lymphoblastic Leukemia in Murine Allogeneic Hematopoietic Stem Cell Transplantation Recipients Treated with.

Advertisements

Hematopoietic Stem Cell Transplantation in Australia and New Zealand,

Relative Survival of Long-Term Hematopoietic Cell Transplant Recipients Approaches General Population Rates Ian Nivison-Smith, Judy M. Simpson, Anthony.

Safety of Live Attenuated High-Titer Varicella-Zoster Virus Vaccine in Pediatric Allogeneic Hematopoietic Stem Cell Transplantation Recipients Takahiro.

How to Treat MDS without Stem Cell Transplantation

Immune Reconstitution after Double Umbilical Cord Blood Stem Cell Transplantation: Comparison with Unrelated Peripheral Blood Stem Cell Transplantation

Thymic Activity and T Cell Repertoire Recovery after Autologous Hematopoietic Stem Cell Transplantation Preceded by Myeloablative Radiotherapy or Chemotherapy

Allogeneic Hematopoietic Cell Transplantation May Alleviate the Negative Prognostic Impact of Monosomal and Complex Karyotypes on Patients with Acute.

Vaccination of Children following Allogeneic Stem Cell Transplantation

Altered Homeostasis of CD4+ Memory T Cells in Allogeneic Hematopoietic Stem Cell Transplant Recipients: Chronic Graft-versus-Host Disease Enhances T Cell.

Humoral Immune Reconstitution Kinetics after Allogeneic Hematopoietic Stem Cell Transplantation in Children: A Maturation Block of IgM Memory B Cells.

A Non-Leaky Artemis-Deficient Mouse That Accurately Models the Human Severe Combined Immune Deficiency Phenotype, Including Resistance to Hematopoietic.

Allogeneic Stem Cell Transplantation in Myelofibrosis

Long-Term Immune Reconstitution of Naive and Memory T Cell Pools after Haploidentical Hematopoietic Stem Cell Transplantation Rita I. Azevedo, Maria.

Sabina Kersting, Leo F. Verdonck

Access to Hematopoietic Cell Transplantation in the United States

Betty T. Tran, Abigail Halperin, Jason W. Chien

A Comparison of the Kinetics of Nucleated Cells and CD34+ Cells in Neonatal Peripheral Blood and Cord Blood Joong-Pyo Kim, Young-Ho Lee, Young-Ah Lee,

Decision Analysis of Peripheral Blood versus Bone Marrow Hematopoietic Stem Cells for Allogeneic Hematopoietic Cell Transplantation Joseph Pidala, Claudio.

Immune Reconstitution after Allogeneic Hematopoietic Cell Transplantation in Children Coco de Koning, Maud Plantinga, Paul Besseling, Jaap Jan Boelens,

Increased Risk of Bone Loss without Fracture Risk in Long-Term Survivors after Allogeneic Stem Cell Transplantation Bipin N. Savani, Theresa Donohue,

Antibody Response to Polysaccharide Conjugate Vaccines after Nonmyeloablative Allogeneic Stem Cell Transplantation Aafke Meerveld-Eggink, Ankie M.T.

Motivations, Experiences, and Perspectives of Bone Marrow and Peripheral Blood Stem Cell Donors: Thematic Synthesis of Qualitative Studies Maria C. Garcia,

Cytomegalovirus Infection after Allogeneic Transplantation: Comparison of Cord Blood with Peripheral Blood and Marrow Graft Sources Christopher M. Walker,

A Process to Facilitate Decision Making in Pediatric Stem Cell Transplantation: The Individualized Care Planning and Coordination Model Justin N. Baker,

Recombinant Human Granulocyte Colony-Stimulating Factor Significantly Decreases the Expression of CXCR3 and CCR6 on T Cells and Preferentially Induces.

Controversies in Lymphoma: The Role of Hematopoietic Cell Transplantation for Mantle Cell Lymphoma and Peripheral T Cell Lymphoma Peter Dreger, Ginna.

Lymphocyte Subset Recovery and Outcome after Autologous Hematopoietic Stem Cell Transplantation for Plasma Cell Myeloma Jessica Rueff, Michael Medinger,

T Cell and B Cell Immunity can be Reconstituted with Mismatched Hematopoietic Stem Cell Transplantation Without Alkylator Therapy in Artemis-Deficient.

Effect of Ex Vivo Culture of CD34+ Bone Marrow Cells on Immune Reconstitution of XSCID Dogs Following Allogeneic Bone Marrow Transplantation Douglas.

Immunologic Resolution of Human Chronic Graft-versus-Host Disease

Follicular Lymphoma: Prognostic Factors, Conventional Therapies, and Hematopoietic Cell Transplantation Laurie H. Sehn, Timothy S. Fenske, Ginna G. Laport

Sarah Nikiforow, Jerome Ritz

Improvement of Pulmonary Function with Imatinib Mesylate in Bronchiolitis Obliterans Following Allogeneic Hematopoietic Cell Transplantation Navneet.

Correlation between the numbers of naive T cells infused with blood stem cell allografts and the counts of naive T cells after transplantation Jan Storek,

Amotosalen-treated donor T cells have polyclonal antigen-specific long-term function without graft-versus-host disease after allogeneic bone marrow transplantation

B Cells and Transplantation: An Educational Resource

Allogeneic Hematopoietic Stem Cell Transplantation in Adult Acute Lymphocytic Leukemia: Impact of Donor Source on Survival Priya Kumar, Todd E. Defor,

Pharmacokinetic Evaluation of the Drug Interaction between Intravenous Itraconazole and Intravenous Tacrolimus or Intravenous Cyclosporin A in Allogeneic.

Sabina Kersting, Ronald J. Hené, Hein A. Koomans, Leo F. Verdonck

Antiviral Responses following L-Leucyl-L-Leucine Methyl Esther (LLME)-Treated Lymphocyte Infusions: Graft-versus-Infection without Graft-versus-Host Disease

Allogeneic Stem Cell Transplantation for Aplastic Anemia

The Hematopoietic Cell Transplant Pharmacist: Roles, Responsibilities, and Recommendations from the ASBMT Pharmacy Special Interest Group Amber B. Clemmons,

Regression Models for Hazard Rates Versus Cumulative Incidence Probabilities in Hematopoietic Cell Transplantation Data Brent R. Logan, Mei-Jie Zhang,

Clinical Strategies to Enhance Posttransplant Immune Reconstitution

Pauline Damien, David S. Allan

Gerard Socié, K. Scott Baker, Smita Bhatia

What is quality in a transplant program?

Issues of Aging and Geriatric Medicine: Relevance to Cancer Treatment and Hematopoietic Reconstitution William B. Ershler, Andrew S. Artz, Evan T. Keller

Interleukin-7–Engineered Mesenchymal Cells: In Vitro Effects on Naive T-Cell Population Paolo Sportoletti, Beatrice Del Papa, Mariangela De Ioanni, Lorenzo.

Chimeric Antigen Receptor–Modified T Cells: Clinical Translation in Stem Cell Transplantation and Beyond Stanley R. Riddell, Michael C. Jensen, Carl.

Systemic Toxoplasmosis Post Allogeneic Stem Cell Transplantation (Allo-SCT): Lessons Learned from HIV? Marie von Lilienfeld-Toal, MD, Maria Gilleece,

Melissa A. Mazur, Craig C. Davis, Paul Szabolcs, MD

Blood and Marrow Transplant Handbook

Bernard Maybury, Gordon Cook, Guy Pratt, Kwee Yong, Karthik Ramasamy

Varicella-Zoster Virus Disease Is More Frequent after Cord Blood Than after Bone Marrow Transplantation Kristel Vandenbosch, Philippe Ovetchkine, Martin.

Pure White Cell Aplasia (PWCA) Relapsing after Allogeneic BMT and Successfully Treated with Nine DLIs A.M. Marmont, A. Dominietto, MD, F. Gualandi, MD,

Reconstitution of T Cell Subset Repertoire Diversity following Multiple Antigen- Mismatched Bone Marrow Transplantation Thea M. Friedman, Olga Azhipa,

Mammen Chandy Biology of Blood and Marrow Transplantation

Successful Immune Reconstitution Decreases Leukemic Relapse and Improves Survival in Recipients of Unrelated Cord Blood Transplantation Robertson Parkman,

Reduced Intensity Conditioning for Allogeneic Hematopoietic Cell Transplantation: Current Perspectives Brenda M. Sandmaier, Stephen Mackinnon, Richard.

Immunologic Recovery in Children after Alternative Donor Allogeneic Transplantation for Hematologic Malignancies: Comparison of Recipients of Partially.

Hematopoietic Stem Cell Transplantation in Australia and New Zealand,

Mary Eapen Biology of Blood and Marrow Transplantation

Correlation of Infused CD3+CD8+ Cells with Single-Donor Dominance after Double-Unit Cord Blood Transplantation Filippo Milano, Shelly Heimfeld, Ted Gooley,

Older Age But Not Donor Health Impairs Allogeneic Granulocyte Colony-Stimulating Factor (G-CSF) Peripheral Blood Stem Cell Mobilization Elie Richa, Mona.

In Memoriam: E. Donnall Thomas

Long-Term Results Of Autologous Hematopoietic Cell Transplantation For Peripheral T Cell Lymphoma: The Stanford Experience Andy I. Chen, Alex McMillan,

Optimal Donor Selection: Beyond HLA

CD137 Expression Identifies Leukemia Specific CTL after in Vitro Priming of Cord Blood T Cells Previously Expanded By CD3/CD28 Co-Stimulation Jeyaraj.

Presentation transcript:

T Cell Repertoire Development in XSCID Dogs Following Nonconditioned Allogeneic Bone Marrow Transplantation William Vernau, Brian J. Hartnett, Douglas R. Kennedy, Peter F. Moore, Paula S. Henthorn, Kenneth I. Weinberg, Peter J. Felsburg Biology of Blood and Marrow Transplantation Volume 13, Issue 9, Pages 1005-1015 (September 2007) DOI: 10.1016/j.bbmt.2007.05.013 Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Classification of TCR Vβ spectratypes. Polyclonal Gaussian distribution (A), polyclonal skewed distribution (B), and oligoclonal distribution (C). Biology of Blood and Marrow Transplantation 2007 13, 1005-1015DOI: (10.1016/j.bbmt.2007.05.013) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Immunologic reconstitution in XSCID dogs following transplantation with whole bone marrow or CD34+ bone marrow cells. Absolute lymphocyte counts (A), proportion of peripheral T cells (B), proportion of peripheral CD45RA+ (naïve) T cells (C), CD4/CD8 ratio (D), proliferative response following stimulation with PHA (E), and IgG speficic antibody response following immunization with tetanus toxoid (F). Biology of Blood and Marrow Transplantation 2007 13, 1005-1015DOI: (10.1016/j.bbmt.2007.05.013) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 TCR Vβ spectratypes of normal dogs and XSCID dogs following bone marrow transplantation. The normal dogs are designated with an N and the bone marrow transplanted dogs designated with B. The numbers following the N represent age of the dog in years and the numbers following the B represent the age in years following transplant. Biology of Blood and Marrow Transplantation 2007 13, 1005-1015DOI: (10.1016/j.bbmt.2007.05.013) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 4 TCR Vβ spectratyping in normal dogs and transplanted XSCID dogs. Each time point represents the summary results from an individual dog. Results are expressed as percentage of total Vβ families representing a polyclonal Gaussian (PG), polyclonal skewed (PS), or oligoclonal (O) phenotype. N-2, N-4, N-7 = normal dogs at 2, 4, and 7 years of age. Biology of Blood and Marrow Transplantation 2007 13, 1005-1015DOI: (10.1016/j.bbmt.2007.05.013) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 5 TCR Vβ spectratypes of three XSCID dogs 3 years following initial evaluation. Dog R743 was evaluated at 4.5 years and 7.5 years posttransplant. Dog X58 was evaluated at 5.5 years and 8.5 years posttransplant. Dog R468 was evaluated at 7.5 years and 10.5 years posttransplant. Biology of Blood and Marrow Transplantation 2007 13, 1005-1015DOI: (10.1016/j.bbmt.2007.05.013) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 6 TCR Vβ spectratyping in 3 transplanted XSCID dogs at initial testing and 3 years later. Results are expressed as percentage of total Vβ families representing a polyclonal Gaussian (PG), polyclonal skewed (PS), or oligoclonal (O) phenotype. Biology of Blood and Marrow Transplantation 2007 13, 1005-1015DOI: (10.1016/j.bbmt.2007.05.013) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions