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Volume 23, Issue 4, Pages 243-250 (December 2016) Resveratrol prevents pulmonary trunk remodeling but not right ventricular hypertrophy in monocrotaline-induced pulmonary hypertension David N. Wilson, Sydney E. Schacht, Layla Al-Nakkash, Jeganathan Ramesh Babu, Tom L. Broderick Pathophysiology Volume 23, Issue 4, Pages 243-250 (December 2016) DOI: 10.1016/j.pathophys.2016.05.004 Copyright © 2016 Elsevier B.V. Terms and Conditions

Fig. 1 Representative image of a transverse section of a whole heart from a control rat. Transverse sections were taken just inferior to the atrial-ventricular septum along the coronary sinus displaying the circular left ventricle (LV) and half-moon-shaped right ventricle (RV). Septum measurements were taken as shown for the interventricular septum (IVS) in black, right ventricle free wall (RVFW) in red, and left ventricle free wall (LVFW) in blue. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.) Pathophysiology 2016 23, 243-250DOI: (10.1016/j.pathophys.2016.05.004) Copyright © 2016 Elsevier B.V. Terms and Conditions

Fig. 2 Effects of monocrotaline and oral resveratrol treatment on total heart surface area (2A) and total muscle area (2B). Values are expressed as mean±SEM for 8 hearts per group. MCT, monocrotaline; RES, resveratrol. * P<0.05 compared to control hearts. Pathophysiology 2016 23, 243-250DOI: (10.1016/j.pathophys.2016.05.004) Copyright © 2016 Elsevier B.V. Terms and Conditions

Fig. 3 Effects of monocrotaline and oral resveratrol treatment on left ventricular lumen area (3A) and right ventricular lumen area (3B). A Log10 transformation was used to normalize the data for the right ventricular lumen area. Values are expressed as mean±SEM for 8 hearts per group. MCT, monocrotaline; RES, resveratrol. * P<0.05 compared to control hearts. Pathophysiology 2016 23, 243-250DOI: (10.1016/j.pathophys.2016.05.004) Copyright © 2016 Elsevier B.V. Terms and Conditions

Fig. 4 Effects of monocrotaline and oral resveratrol treatment of interventricular septum thickness (4A), left ventricular wall thickness (4B), and right ventricular wall thickness (4C). Values are expressed as mean±SEM for 8 hearts per group. MCT, monocrotaline; RES, resveratrol; IVS, interventricular septum; LV, left ventricle; RV, right ventricle. Pathophysiology 2016 23, 243-250DOI: (10.1016/j.pathophys.2016.05.004) Copyright © 2016 Elsevier B.V. Terms and Conditions

Fig. 5 Effects of monocrotaline and oral resveratrol treatment on cardiac fibrosis content. Values are expressed as mean±SEM for 8 hearts per group. MCT, monocrotaline; RES, resveratrol. * P<0.05 compared to control hearts. Pathophysiology 2016 23, 243-250DOI: (10.1016/j.pathophys.2016.05.004) Copyright © 2016 Elsevier B.V. Terms and Conditions

Fig. 6 Effects of monocrotaline and oral resveratrol treatment on pulmonary artery lumen area. Values are expressed as mean±SEM for 8 hearts per group. MCT, monocrotaline; RES, resveratrol. Pathophysiology 2016 23, 243-250DOI: (10.1016/j.pathophys.2016.05.004) Copyright © 2016 Elsevier B.V. Terms and Conditions

Fig. 7 Effects of monocrotaline and oral resveratrol treatment on pulmonary artery tunica media thickness. Fig. 7A illustrates that hypertrophy if the tunica media in MCT rats was prevented with resveratrol treatment. Light microscopy images of pulmonary trunk vessels obtained from control (7B), MCT-treated rats (7C), and MCT and RES-treated rats (7D). As illustrated in Fig. 7C, a single injection of MCT in a Sprague-Dawley rat induced significant thickening of the tunica media. In 7D, the pulmonary artery is showing reduced medial hypertrophy after 21days of oral resveratrol treatment. Values are expressed as mean±SEM for 8 hearts per group. MCT, monocrotaline; RES, resveratrol. * P<0.05 compared to control hearts. † P<0.05 compared to MCT hearts. Pathophysiology 2016 23, 243-250DOI: (10.1016/j.pathophys.2016.05.004) Copyright © 2016 Elsevier B.V. Terms and Conditions