Liquids, Fibers, and Gels: The Many Phases of Neurodegeneration

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Liquids, Fibers, and Gels: The Many Phases of Neurodegeneration Shana Elbaum-Garfinkle, Clifford P. Brangwynne Developmental Cell Volume 35, Issue 5, Pages 531-532 (December 2015) DOI: 10.1016/j.devcel.2015.11.014 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Model of FUS Protein Assemblies FUS wild-type protein can assemble into liquid or hydrogel states that can be fully reversed to a mixed bulk solution. FUS ALS/FTD mutations lead to assembly of liquids and/or gels that can no longer be reversed, resulting in the retention of additional proteins. This insoluble, irreversible protein phase correlates with deteriorated motor nerve function and decreased lifespan, characteristic of ALS/FTD diseases. Developmental Cell 2015 35, 531-532DOI: (10.1016/j.devcel.2015.11.014) Copyright © 2015 Elsevier Inc. Terms and Conditions