Volume 146, Issue 5, Pages 1231-1239.e6 (May 2014) A Histologic Scoring System for Prognosis of Patients With Alcoholic Hepatitis  José Altamirano, Rosa Miquel, Aezam Katoonizadeh, Juan G. Abraldes, Andrés Duarte–Rojo, Alexandre Louvet, Salvador Augustin, Rajeshwar P. Mookerjee, Javier Michelena, Thomas C. Smyrk, David Buob, Emmanuelle Leteurtre, Diego Rincón, Pablo Ruiz, Juan Carlos García–Pagán, Carmen Guerrero–Marquez, Patricia D. Jones, A. Sidney Barritt, Vicente Arroyo, Miquel Bruguera, Rafael Bañares, Pere Ginès, Juan Caballería, Tania Roskams, Frederik Nevens, Rajiv Jalan, Philippe Mathurin, Vijay H. Shah, Ramón Bataller  Gastroenterology  Volume 146, Issue 5, Pages 1231-1239.e6 (May 2014) DOI: 10.1053/j.gastro.2014.01.018 Copyright © 2014 AGA Institute Terms and Conditions

Figure 1 Histologic features independently associated with 90-day survival included in the Histologic AHHS. (A–C) Degree of fibrosis (Masson trichrome staining): portal fibrosis, expansive areas of liver fibrosis, and cirrhosis, respectively. H&E stain. Gastroenterology 2014 146, 1231-1239.e6DOI: (10.1053/j.gastro.2014.01.018) Copyright © 2014 AGA Institute Terms and Conditions

Figure 2 Histologic features independently associated with 90-day survival included in the Histologic AHHS. (A) Hepatocellular and canalicular bilirubinostasis (arrow). (B) Ductular bilirubinostasis (arrow). (C) Megamitochondria (arrows). (D and E) Mild and severe PMN infiltration, respectively (arrow). H&E stain. Gastroenterology 2014 146, 1231-1239.e6DOI: (10.1053/j.gastro.2014.01.018) Copyright © 2014 AGA Institute Terms and Conditions

Figure 3 Three-month survival probability of patients with AH according to the Histologic AHHS in the (A) study and (B) validation cohorts. Gastroenterology 2014 146, 1231-1239.e6DOI: (10.1053/j.gastro.2014.01.018) Copyright © 2014 AGA Institute Terms and Conditions

Figure 4 (A) Three-month survival probability of patients with ABIC class B according to the AHHS. (B) Three-month survival probability of patients with a MELD score <21 according to the AHHS. Gastroenterology 2014 146, 1231-1239.e6DOI: (10.1053/j.gastro.2014.01.018) Copyright © 2014 AGA Institute Terms and Conditions

Supplementary Figure 1 Three-month probability of survival in patients with AH treated with corticosteroids according to the AHHS). Gastroenterology 2014 146, 1231-1239.e6DOI: (10.1053/j.gastro.2014.01.018) Copyright © 2014 AGA Institute Terms and Conditions

Supplementary Figure 2 Predicted vs observed mortality in the validation set according to the AHHS. Gastroenterology 2014 146, 1231-1239.e6DOI: (10.1053/j.gastro.2014.01.018) Copyright © 2014 AGA Institute Terms and Conditions

Supplementary Figure 3 Type of bilirubinostasis and infections during hospitalizations in patients with AH. Gastroenterology 2014 146, 1231-1239.e6DOI: (10.1053/j.gastro.2014.01.018) Copyright © 2014 AGA Institute Terms and Conditions

Supplementary Figure 4 Type of bilirubinostasis and baseline serum bilirubin levels. Gastroenterology 2014 146, 1231-1239.e6DOI: (10.1053/j.gastro.2014.01.018) Copyright © 2014 AGA Institute Terms and Conditions

Supplementary Figure 5 Side-by-side comparison of AHHS, ABIC score, and MELD score for predicting 90-day mortality in the complete cohort. Gastroenterology 2014 146, 1231-1239.e6DOI: (10.1053/j.gastro.2014.01.018) Copyright © 2014 AGA Institute Terms and Conditions

Supplementary Figure 6 Differences in the MELD score between patients with an AHHS ≥5 points and an AHHS <5 points. Gastroenterology 2014 146, 1231-1239.e6DOI: (10.1053/j.gastro.2014.01.018) Copyright © 2014 AGA Institute Terms and Conditions

Supplementary Figure 7 Measurement of HVPG in patients with an AHHS ≥5 points and an AHHS <5 points in the complete cohort. Gastroenterology 2014 146, 1231-1239.e6DOI: (10.1053/j.gastro.2014.01.018) Copyright © 2014 AGA Institute Terms and Conditions

Supplementary Figure 8 AUROC for agreement between predicted and observed probabilities of mortality. AUROC, area under the receiver operating characteristic curve. Gastroenterology 2014 146, 1231-1239.e6DOI: (10.1053/j.gastro.2014.01.018) Copyright © 2014 AGA Institute Terms and Conditions