Postsynaptic currents and potentials

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Presentation transcript:

Postsynaptic currents and potentials NMJ: ACh CNS: Excitation by glutamate Inhibition by GABA Reversal potentials for synaptic currents

NMJ postsynaptic current : opening of ligand gated channels

The electrochemical driving force muscle equilibrium potentials: K+: -100mV Na+: +70mV Cl-: - 50mV Resting Vm: -90mV Reversal: 0mV Important: if conductance of the channel is not sensitive to Vm (ligand-, not voltage-gated), direction of the current is determined by electrochemical driving force. E(drive) = Vm – E(rev) EPC = g(ACh) * E(drive)

Vm dependent action of a neurotransmitter the action of a transmitter drives the postsynaptic membrane potential toward Erev for the particular ion channels being activated.

Glutamatergic EPSC

AMPA receptor

NMDA receptor

AMPA - NMDA receptor interaction Weak stimulus Strong stimulus

Inhibition – GABA receptors

GABA receptor Vm dependence

GABA receptor with high internal Cl- Normal Cl- concentrations [Cl-]in: ~5mM [Cl-]out: ~110mM

Integration of EPSP and IPSP

Inhibition regardless of PSP direction? Depending on the cell’s Vm (or other factors such as [Cl-] in/out or neuromodulators) GABAergic current can cause hyperpolarization or depolarization.

Presynaptic inhibition