Oxidative Stress and Atrial Fibrillation After Cardiac Surgery: A Case-Control Study Basel Ramlawi, MD, MMSc, Hasan Otu, PhD, Shigetoshi Mieno, MD, Munir.

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Presentation transcript:

Oxidative Stress and Atrial Fibrillation After Cardiac Surgery: A Case-Control Study Basel Ramlawi, MD, MMSc, Hasan Otu, PhD, Shigetoshi Mieno, MD, Munir Boodhwani, MD, Neel R. Sodha, MD, Richard T. Clements, PhD, Cesario Bianchi, MD, PhD, Frank W. Sellke, MD The Annals of Thoracic Surgery Volume 84, Issue 4, Pages 1166-1173 (October 2007) DOI: 10.1016/j.athoracsur.2007.04.126 Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 (A) Fold change of right atrial and skeletal muscle protein oxidation (after cardiopulmonary bypass [post-CPB] versus before cardiopulmonary bypass [pre-CPB]), showing acute increase in myocardial protein oxidation associated with postoperative atrial fibrillation (PAF). Patients exhibiting postoperative atrial fibrillation display significantly more myocardial oxidation than patients in normal sinus rhythm (SR). No difference was observed in skeletal muscle oxidation between groups. (B) Representative immunoblots. (A = after cardiopulmonary bypass; B = before cardiopulmonary bypass; PAF = postoperative atrial fibrillation, SR = sinus rhythm.) The Annals of Thoracic Surgery 2007 84, 1166-1173DOI: (10.1016/j.athoracsur.2007.04.126) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 (A) Serum peroxide fold change was significantly higher in patients with postoperative atrial fibrillation (PAF) compared with patients in normal sinus rhythm (SR) at 6-hour time point (6H). (NS = not significant; POD4 = postoperative day 4.) (B) Relationship of peroxide level fold change in serum to myocardial oxidation. Serum peroxide levels were significantly correlated with myocardial protein oxidation. (PRE = preoperative; 6H = 6 hours postoperative.) The Annals of Thoracic Surgery 2007 84, 1166-1173DOI: (10.1016/j.athoracsur.2007.04.126) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Hierarchical clustering dendogram of gene expression of patients with postoperative atrial fibrillation and those in normal sinus rhythm before (P) and after (I) cardiopulmonary bypass. (1 = atrial fibrillation [Afib] present; 0 = sinus rhythm.) The Annals of Thoracic Surgery 2007 84, 1166-1173DOI: (10.1016/j.athoracsur.2007.04.126) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Genes that were differentially expressed after cardiopulmonary bypass (CPB) in patients with postoperative atrial fibrillation (PAF) and in patients in normal sinus rhythm (SR). (A) Upregulated genes (6 hours versus preoperative). (B) Downregulated genes (6 hours versus preoperative). The Annals of Thoracic Surgery 2007 84, 1166-1173DOI: (10.1016/j.athoracsur.2007.04.126) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions