Volume 16, Issue 1, Pages (January 2017)

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Volume 16, Issue 1, Pages 33-42 (January 2017) Safety and effectiveness of hormonal treatment versus hormonal treatment with vigabatrin for infantile spasms (ICISS): a randomised, multicentre, open-label trial Dr Finbar J K O'Callaghan, PhD, Stuart W Edwards, PhD, Fabienne Dietrich Alber, MSc, Eleanor Hancock, MD, Anthony L Johnson, PhD, Prof Colin R Kennedy, MD, Marcus Likeman, FRCR, Andrew L Lux, PhD, Mark Mackay, PhD, Andrew A Mallick, PhD, Richard W Newton, MD, Melinda Nolan, MBBS, Ronit Pressler, PhD, Prof Dietz Rating, MD, Prof Bernhard Schmitt, MD, Christopher M Verity, FRCPCH, Prof John P Osborne, MD The Lancet Neurology Volume 16, Issue 1, Pages 33-42 (January 2017) DOI: 10.1016/S1474-4422(16)30294-0 Copyright © 2016 Elsevier Ltd Terms and Conditions

Figure 1 Trial design for assessment of primary clinical outcome The trial continued after the assessment of primary clinical outcome with developmental assessment at 18 and 42 months of age. The Lancet Neurology 2017 16, 33-42DOI: (10.1016/S1474-4422(16)30294-0) Copyright © 2016 Elsevier Ltd Terms and Conditions

Figure 2 Trial profile The Lancet Neurology 2017 16, 33-42DOI: (10.1016/S1474-4422(16)30294-0) Copyright © 2016 Elsevier Ltd Terms and Conditions