A network-based analysis of the late-phase reaction of the skin

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Presentation transcript:

A network-based analysis of the late-phase reaction of the skin Mikael Benson, MD, PhD, Michael A. Langston, PhD, Mikael Adner, PhD, Bengt Andersson, MD, PhD, Åsa Torinssson-Naluai, PhD, Lars Olaf Cardell, MD, PhD Journal of Allergy and Clinical Immunology Volume 118, Issue 1, Pages 220-225 (July 2006) DOI: 10.1016/j.jaci.2006.03.006 Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 Network representation of interactions between differentially expressed genes from a DNA microarray analysis of allergen-challenged skin from allergic patients and healthy control subjects. Of 1840 differentially expressed genes, a total of 50 statistically significant networks were formed. The networks were scored according to significance. The figure shows the top-scoring networks 1 (A) and 2 (B). Genes that are colored red have higher expression in patients than in control subjects, and genes colored green have lower expression in patients. Journal of Allergy and Clinical Immunology 2006 118, 220-225DOI: (10.1016/j.jaci.2006.03.006) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions