Facilitating Translational Nanomedicine via Predictive Safety Assessment  Vahid Mirshafiee, Wen Jiang, Bingbing Sun, Xiang Wang, Tian Xia  Molecular Therapy  Volume 25, Issue 7, Pages 1522-1530 (July 2017) DOI: 10.1016/j.ymthe.2017.03.011 Copyright © 2017 The American Society of Gene and Cell Therapy Terms and Conditions

Molecular Therapy 2017 25, 1522-1530DOI: (10.1016/j.ymthe.2017.03.011) Copyright © 2017 The American Society of Gene and Cell Therapy Terms and Conditions

Figure 1 Major Exposure Routes of ENMs with Distinct Physicochemical Properties for Medicinal Applications Physicochemical properties of ENMs and their route of administration determine their interaction at the nano-bio interface and cytotoxicity. Molecular Therapy 2017 25, 1522-1530DOI: (10.1016/j.ymthe.2017.03.011) Copyright © 2017 The American Society of Gene and Cell Therapy Terms and Conditions

Figure 2 SARs Linking ENM Physicochemical Properties to Adverse Outcome Pathways Examples of ENM-induced toxicity mechanisms include lysosomal damage by cationic nanocarriers, NLRP3 inflammasome activation for REO NPs and high aspect ratio nanomaterials, membrane perturbation by 2D nanomaterials and Si-NPs, and lipid peroxidation and ROS generation by silver and metal oxide NPs. Molecular Therapy 2017 25, 1522-1530DOI: (10.1016/j.ymthe.2017.03.011) Copyright © 2017 The American Society of Gene and Cell Therapy Terms and Conditions