Volume 4, Issue 9, Pages (October 2018)

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Volume 4, Issue 9, Pages 921-923 (October 2018) Tumoral melanosis associated with combined BRAF/MEK inhibition (dabrafenib/trametinib) in metastatic melanoma Antonia Laino, MBBS, Benjamin Shepherd, MBBS, FACP, Victoria Atkinson, MBBS, FRACP, Hong Fu, BN, H. Peter Soyer, MD, FACD, Helmut Schaider, MD, FACD JAAD Case Reports Volume 4, Issue 9, Pages 921-923 (October 2018) DOI: 10.1016/j.jdcr.2018.06.024 Copyright © 2018 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Surveillance image of participant using Vectra WB360 3D Whole Body Imaging System and associated dermoscopic image of left popliteal fossa mimicking a nodular melanoma (lesion 38). Dermoscopic features of interest include a central 10- x 9-mm purple-black, nonulcerated nodule (star) with an adjacent brown-black macule with peripheral brown clods (arrows). JAAD Case Reports 2018 4, 921-923DOI: (10.1016/j.jdcr.2018.06.024) Copyright © 2018 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 A, Large nodular collection of heavily pigmented melanophages in the dermis. No viable melanoma cells were identified. B, Immunohistochemistry shows strong positive staining for CD68 and C, negative staining for S100. (A, Hematoxylin-eosin stain; C, red chromagen; original magnifications: A, x20; B and C, x100.) JAAD Case Reports 2018 4, 921-923DOI: (10.1016/j.jdcr.2018.06.024) Copyright © 2018 American Academy of Dermatology, Inc. Terms and Conditions