A randomized placebo-controlled study on the effects of pioglitazone on cortisol metabolism in polycystic ovary syndrome Dorte Glintborg, M.D., Ph.D.,

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Presentation transcript:

A randomized placebo-controlled study on the effects of pioglitazone on cortisol metabolism in polycystic ovary syndrome Dorte Glintborg, M.D., Ph.D., Anne Pernille Hermann, M.D., Ph.D., Claus Hagen, M.D., Dr.Sci., Lars Thorbjørn Jensen, M.D., Jan Frystyk, M.D., Ph.D., Dr.Sci., Paul Bennett, Ph.D., Allan Flyvbjerg, M.D., Dr.Sci., Marianne Andersen, M.D., Ph.D. Fertility and Sterility Volume 91, Issue 3, Pages 842-850 (March 2009) DOI: 10.1016/j.fertnstert.2007.12.082 Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Scatterplots of correlations between changes in (A) insulin-like growth factor I (IGF-l), (B) peak growth hormone (GH), and (C) adiponectin vs. changes in measures of relative 5α-reductase activity in all PCOS patients (solid line) and during pioglitazone treatment (dashed line). A/E = androsterone/etiocholanolone ratio; THF = tetrahydrocortisol. Fertility and Sterility 2009 91, 842-850DOI: (10.1016/j.fertnstert.2007.12.082) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions