Secular trends of bloodstream infections during neutropenia in 15 181 haematopoietic stem cell transplants: 13-year results from a European multicentre.

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Secular trends of bloodstream infections during neutropenia in 15 181 haematopoietic stem cell transplants: 13-year results from a European multicentre.

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Secular trends of bloodstream infections during neutropenia in 15 181 haematopoietic stem cell transplants: 13-year results from a European multicentre surveillance study (ONKO-KISS) M. Weisser, C. Theilacker, S. Tschudin Sutter, R. Babikir, H. Bertz, T. Götting, M. Dettenkofer, W.V. Kern, A.F. Widmer Clinical Microbiology and Infection Volume 23, Issue 11, Pages 854-859 (November 2017) DOI: 10.1016/j.cmi.2017.03.020 Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 1 Trends in incidence of bloodstream infections (BSI) during neutropenia after haematopoietic stem cell transplantation (HSCT). (A) Incidence of BSI in patients after autologous HSCT. (B) Incidence of BSI in patients after allogeneic HSCT. In patients after autologous HSCT, Gram-negative BSI increased (p 0.001), and Gram-positive BSI decreased significantly between 2002 and 2014 (p <0.001). In patients after allogeneic HSCT, Gram-negative BSI increased significantly (p <0.001). Trends in BSI incidence were examined by chi-square test for trend. Clinical Microbiology and Infection 2017 23, 854-859DOI: (10.1016/j.cmi.2017.03.020) Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 2 Trends in incidence of bloodstream infections (BSI) during neutropenia after haematopoietic stem cell transplantation (HSCT) according to pathogen. Incidence of BSI in patients after autologous HSCT (A) and in patients after allogeneic (HSCT) (B). Between 2002 and 2010, drop in incidence of BSI caused by coagulase-negative staphylococci was observed after autologous (p 0.028) and after allogeneic HSCT (p <0.001). Nonsignificant trends in incidence of BSI with coagulase-negative staphylococci occurred after 2010. In addition, incidence of BSI by Enterococcus spp. and Escherichia coli increased in patients with allogeneic HSCT (p <0.001, respectively). Trends in incidence of BSI were examined by chi-square test for trend. Clinical Microbiology and Infection 2017 23, 854-859DOI: (10.1016/j.cmi.2017.03.020) Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 3 Bloodstream infections in haematopoietic stem cell transplantation patients infected with multidrug-resistant bacteria. (A) Methicillin-resistant Staphylococcus aureus. (B) Vancomycin-resistant enterococci. (C) Extended-spectrum β-lactamase-producing Enterobacteriacea. n.c., not cultured. Clinical Microbiology and Infection 2017 23, 854-859DOI: (10.1016/j.cmi.2017.03.020) Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Clinical Microbiology and Infection 2017 23, 854-859DOI: (10. 1016/j Clinical Microbiology and Infection 2017 23, 854-859DOI: (10.1016/j.cmi.2017.03.020) Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions