Modulation of the Sleep State–Dependent P50 Midlatency Auditory-Evoked Potential by Electric Stimulation of Acupuncture Points  Patricia A. Bray, BA, Noriaki Mamiya, MD, Alice V. Fann, MD, Harris Gellman, MD, Robert D. Skinner, PhD, Edgar E. Garcia-Rill, PhD  Archives of Physical Medicine and Rehabilitation  Volume 86, Issue 10, Pages 2018-2026 (October 2005) DOI: 10.1016/j.apmr.2004.11.047 Copyright © 2005 American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation Terms and Conditions

Fig 1 Investigation 2: P50 potential amplitude after electroacupuncture at a low frequency (5Hz). P50 potential amplitude, normalized, was recorded at baseline (control [CTL]=100%) and every 6 to 7 minutes thereafter for a total of 8 repeated measures. The amplitude of the P50 potential was reduced significantly at S2, S3, P3, and P4 (1-way ANOVA, *P<.05; †P<.01). Abbreviation: Pts, points. Archives of Physical Medicine and Rehabilitation 2005 86, 2018-2026DOI: (10.1016/j.apmr.2004.11.047) Copyright © 2005 American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation Terms and Conditions

Fig 2 Investigation 4: P50 potential amplitude after electroacupuncture at a high frequency (100Hz). Three P50 potential averages (S1, S2, S3) were recorded. Repeated-measures 2-way ANOVA revealed that the amplitude did not differ significantly for the repeated measures (F7,1=1.877, P=.076). However, post hoc testing revealed that P50 potential amplitude was significantly reduced at 1 point (S2*) during stimulation (Newman-Keuls, P<.05). The same measures as in the stimulated group were recorded every 6 minutes for a no-stimulation group with surface electrodes but without electroacupuncture stimulation. The difference between the 2 groups was not statistically significant (repeated-measures 1-way ANOVA, F7,22=3.274; Newman-Keuls, P=.084). Abbreviation: NS, not significant. Archives of Physical Medicine and Rehabilitation 2005 86, 2018-2026DOI: (10.1016/j.apmr.2004.11.047) Copyright © 2005 American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation Terms and Conditions

Fig 3 Investigation 5: P50 potential amplitude after electroacupuncture at 3 control points versus electroacupuncture at 3 specific points. Subjects received 5-Hz electroacupuncture stimulation to 3 control points (GB34, LI11, SI3). S1, S2, and S3 are the 3 P50 potential averages. PS1-PS4 were made after stimulation. The same measures were recorded every 6 minutes for the 3 specific points group with 5-Hz electroacupuncture stimulation. Archives of Physical Medicine and Rehabilitation 2005 86, 2018-2026DOI: (10.1016/j.apmr.2004.11.047) Copyright © 2005 American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation Terms and Conditions

Fig 4 Investigation 6: P50 potential amplitude after electroacupuncture at 3 specific points unilaterally versus bilaterally. Subjects (n=7) received 5-Hz electroacupuncture stimulation unilaterally via surface electrodes on the 3 specific acupuncture points. Three P50 potential averages were recorded: S1, S2, and S3. Four additional averages (P1-P4) were recorded after stimulation. The same measures as in the unilateral group were recorded every 6 minutes for the bilateral group stimulated at 5Hz. Archives of Physical Medicine and Rehabilitation 2005 86, 2018-2026DOI: (10.1016/j.apmr.2004.11.047) Copyright © 2005 American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation Terms and Conditions

Fig 5 Investigation 7: P50 potential amplitude after electroacupuncture at 3 specific points during 3 episodes of stimulation at 5Hz versus no stimulation. Archives of Physical Medicine and Rehabilitation 2005 86, 2018-2026DOI: (10.1016/j.apmr.2004.11.047) Copyright © 2005 American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation Terms and Conditions