Establishment of Xenogeneic Lung Chronic Graft-Verus-Host Disease Mice Model Hisaki Fujii, MD, PhD, Zhijuan Luo, MD, Xinghua Wang, MD, Susan Newbigging,

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Establishment of Xenogeneic Lung Chronic Graft-Verus-Host Disease Mice Model Hisaki Fujii, MD, PhD, Zhijuan Luo, MD, Xinghua Wang, MD, Susan Newbigging, MSc, DVM, DVSc, Armand Keating, MD, R. Maarten Egeler, MD, PhD Biology of Blood and Marrow Transplantation Volume 20, Issue 2, Pages S266-S267 (February 2014) DOI: 10.1016/j.bbmt.2013.12.449 Copyright © 2014 Terms and Conditions

Figure 1 Engraftment of human cells in NSG mice Lung or liver from NSG mice 8 weeks post transplantation were examined for human CD4, CD8, CD20 and CD68 engraftment by IHC. Three randomly selected sections per slide were observed under the x40 objective. Data were calculated as: % positive cells = positive nuclei cells Ú total cells nuclei x 100. Biology of Blood and Marrow Transplantation 2014 20, S266-S267DOI: (10.1016/j.bbmt.2013.12.449) Copyright © 2014 Terms and Conditions

Figure 2 Lung fibrosis in NSG mice 8 weeks after transplantation The lung from NSG mouse bearing PBMCs (A) or CD34+ cells (B) 8 weeks after transplantation was stained with Masson's trichrome. Fibrosis is shown in blue. Biology of Blood and Marrow Transplantation 2014 20, S266-S267DOI: (10.1016/j.bbmt.2013.12.449) Copyright © 2014 Terms and Conditions