Harnessing Host Defenses to HIV

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Harnessing Host Defenses to HIV Cell Volume 155, Issue 3, (October 2013) DOI: 10.1016/j.cell.2013.10.017 Copyright © 2013 Terms and Conditions

The HIV drug maraviroc (orange) locks CCR5 (blue) in an inactive conformation. Image courtesy of B. Wu. Cell 2013 155, DOI: (10.1016/j.cell.2013.10.017) Copyright © 2013 Terms and Conditions

Reverse-transcribed HIV cDNA binds to and activates cGAS, which produces the second messenger cGAMP to activate STING and trigger innate immune responses. Figure courtesy of D. Gao. Cell 2013 155, DOI: (10.1016/j.cell.2013.10.017) Copyright © 2013 Terms and Conditions

Some interferon-stimulated genes (ISGs) inhibit HIV DNA (blue) synthesis, and MX2 (orange) prevents its nuclear accumulation. Figure courtesy of M. Malim. Cell 2013 155, DOI: (10.1016/j.cell.2013.10.017) Copyright © 2013 Terms and Conditions