The implications of anatomical and functional changes of the aging kidney: with an emphasis on the glomeruli Richard J. Glassock, Andrew D. Rule Kidney.

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The implications of anatomical and functional changes of the aging kidney: with an emphasis on the glomeruli Richard J. Glassock, Andrew D. Rule Kidney International Volume 82, Issue 3, Pages 270-277 (August 2012) DOI: 10.1038/ki.2012.65 Copyright © 2012 International Society of Nephrology Terms and Conditions

Figure 1 Mosaic plot of sclerosis scores by age group among 1203 living kidney donors. Sclerosis score defined as the total number of chronic histological abnormalities between (1) any global glomerulosclerosis, (2) any tubular atrophy, (3) interstitial fibrosis >5%, and (4) any arteriosclerosis. In the figure, a score of 0 is white, a score of 4 is orange, and intermediate scores are on a color intensity scale. The figure is used with permission.97 Kidney International 2012 82, 270-277DOI: (10.1038/ki.2012.65) Copyright © 2012 International Society of Nephrology Terms and Conditions

Figure 2 Logarithmic glomerular density by age for persons with ≤10% (solid smoothing spline) or with >10% (dashed smoothing spline) glomerulosclerosis among 1046 living kidney donors. The figure is used with permission.27 Kidney International 2012 82, 270-277DOI: (10.1038/ki.2012.65) Copyright © 2012 International Society of Nephrology Terms and Conditions

Figure 3 A comparison of estimated glomerular filtration rate (GFR) in two ‘normal’ cohorts according to age. (a) Men; (b) Women. Blue lines indicate mean, 90% UPL and LPL estimated glomerular filtration rate (eGFR; modification of diet in renal disease formula (MDRD), re-expressed equation) in healthy living donors. Orange lines indicate median, 5th, and 95th percentiles for ‘normal’ Caucasian community living adults from the Nijmegen Biomedical Study. UPL, upper probability limit; LPL, lower probability limit. The figure is used with permission.66 Kidney International 2012 82, 270-277DOI: (10.1038/ki.2012.65) Copyright © 2012 International Society of Nephrology Terms and Conditions