Comparative Effects of Inhaled Isoproterenol and Vasoactive Intestinal Peptide on Histamine-Induced Bronchoconstriction in Human Subjects Ralph J. Altiere,

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Presentation transcript:

Comparative Effects of Inhaled Isoproterenol and Vasoactive Intestinal Peptide on Histamine-Induced Bronchoconstriction in Human Subjects Ralph J. Altiere, Ph.D., Markus Küng, M.D., Louis Diamond, Ph.D. CHEST Volume 86, Issue 1, Pages 153-154 (July 1984) DOI: 10.1378/chest.86.1.153 Copyright © 1984 The American College of Chest Physicians Terms and Conditions

Figure 1 Effects of aerosolized isoproterenol and vasoactive intestinal peptide (VIP) on histamine induced bronchoconstriction in two human subjects: subject 1, asymptomatic asthmatic (•, ○) and subject 2, nonasthmatic (▲,7). A. Two control histamine challenges administered at 5 h intervals. B, C and D-effects of isoproterenol and VIP on responses to histamine challenge conducted 5 h apart. Each treatment was administered on a separate day. BL = baseline; V = vehicle; cumulative dose of histamine = sum (histamine concentration in mg/ml × number of breaths taken). CHEST 1984 86, 153-154DOI: (10.1378/chest.86.1.153) Copyright © 1984 The American College of Chest Physicians Terms and Conditions