Study of the time course of the clinical effect of propofol compared with the time course of the predicted effect-site concentration: performance of three.

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Presentation transcript:

Study of the time course of the clinical effect of propofol compared with the time course of the predicted effect-site concentration: performance of three pharmacokinetic– dynamic models  M. Coppens, J.G.M. Van Limmen, T. Schnider, B. Wyler, S. Bonte, F. Dewaele, M.M.R.F. Struys, H.E.M. Vereecke  British Journal of Anaesthesia  Volume 104, Issue 4, Pages 452-458 (April 2010) DOI: 10.1093/bja/aeq028 Copyright © 2010 The Author(s) Terms and Conditions

Fig 1 The individual plasma- (dotted line) and effect-site concentrations (full line) vs time in Group M (Marsh's model) (a), Group S1 (Schnider's model with fixed ke0) (b), and Group S2 (Schnider's model with fixed TTPE) (c). British Journal of Anaesthesia 2010 104, 452-458DOI: (10.1093/bja/aeq028) Copyright © 2010 The Author(s) Terms and Conditions

Fig 2 The individual BIS values vs time and their respective mean BIS values (sd) in Group M (Marsh's model) (a and b), Group S1 (Schnider's model with fixed ke0) (c and d), and Group S2 (Schnider's model with fixed TTPE) (e and f). ★Steady-state condition in BIS. British Journal of Anaesthesia 2010 104, 452-458DOI: (10.1093/bja/aeq028) Copyright © 2010 The Author(s) Terms and Conditions

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