Regional Emphysema Score Predicting Overall Survival, Quality of Life, and Pulmonary Function Recovery in Early-Stage Lung Cancer Patients Jie Dai, PhD,

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Regional Emphysema Score Predicting Overall Survival, Quality of Life, and Pulmonary Function Recovery in Early-Stage Lung Cancer Patients Jie Dai, PhD, Ming Liu, MD, Stephen J. Swensen, MD, Shawn M. Stoddard, RN, Jason A. Wampfler, BS, Andrew H. Limper, MD, Gening Jiang, MD, Ping Yang, MD, PhD Journal of Thoracic Oncology Volume 12, Issue 5, Pages 824-832 (May 2017) DOI: 10.1016/j.jtho.2017.01.016 Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

Figure 1 Study population. Abbreviation: CT, computed tomography. Journal of Thoracic Oncology 2017 12, 824-832DOI: (10.1016/j.jtho.2017.01.016) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

Figure 2 Quality of life within 2 years after treatment. (A) Lung cancer in the emphysematous region with surgical resection. (B) Lung cancer in the nonemphysematous region with surgical resection. (C) Lung cancer with nonsurgical treatment. (Outer circle represents a higher score and better quality of life; *p < 0.05 and difference >1 point.) Journal of Thoracic Oncology 2017 12, 824-832DOI: (10.1016/j.jtho.2017.01.016) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

Figure 3 Kaplan-Meier curves for overall survival between different regional emphysema scores (RESs) in three groups: lung cancer in the emphysematous region with surgical resection (A); lung cancer in the nonemphysematous region with surgical resection (B); and lung cancer with nonsurgical treatment (C). There were significant differences in overall survival among patients with mild, moderate, and severe RESs in surgically treated lung cancer, regardless of tumor location (p < 0.01). This difference was insignificant between patients with mild RESs and those with moderate/severe RESs when lung cancer was treated nonsurgically (p = 0.90). Journal of Thoracic Oncology 2017 12, 824-832DOI: (10.1016/j.jtho.2017.01.016) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

Supplementary Figure 1 Postoperative pulmonary function changes within 2 years. Values were expressed as the changes from preoperative evaluation to postoperative evaluation. Group 1, tumor in emphysematous region; Group 2, tumor in non-emphysematous region. (FEV1: forced expiratory volume in 1 second; FVC: forced vital capacity; TLC: total lung capacity; RV: residual volume; DLCO: diffusion capacity of lung for carbon monoxide) Journal of Thoracic Oncology 2017 12, 824-832DOI: (10.1016/j.jtho.2017.01.016) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions