Volume 94, Issue 5, Pages (November 2018)

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Volume 94, Issue 5, Pages 983-992 (November 2018) Serum levels of the adipokine zinc-alpha2-glycoprotein (ZAG) predict mortality in hemodialysis patients Anaïs Bouchara, Dan Yi, Myriam Pastural, Samuel Granjon, Jean-Christophe Selag, Maurice Laville, Walid Arkouche, Solenne Pelletier, Denis Fouque, Christophe O. Soulage, Laetitia Koppe Kidney International Volume 94, Issue 5, Pages 983-992 (November 2018) DOI: 10.1016/j.kint.2018.07.019 Copyright © 2018 International Society of Nephrology Terms and Conditions

Figure 1 Kaplan-Meier estimates of cumulative survival of all patients according to plasma zinc-alpha2-glycoprotein (ZAG) levels at the time of inclusion. Tertile cutoff (log-transformed ZAG level): tertile 1, <1.85 μg/ml; tertile 2, 1.85–2.28 μg/ml; tertile 3, 2.29 μg/ml. The number of events was 12, 13, and 24 for tertile 1, tertile 2, and tertile 3, respectively. The number of patients indicated in the table is the number of patients still followed at the indicated time. Kidney International 2018 94, 983-992DOI: (10.1016/j.kint.2018.07.019) Copyright © 2018 International Society of Nephrology Terms and Conditions

Figure 2 Kaplan-Meier estimates of time to first cardiovascular event according to plasma zinc-alpha2-glycoprotein (ZAG) levels at the time of inclusion. Tertile cutoff (log-transformed ZAG level): tertile 1, <1.85 μg/ml; tertile 2, 1.85–2.28 μg/ml; tertile 3, >2.29 μg/ml. The number of events was 12, 20, and 30 for tertile 1, tertile 2, and tertile 3, respectively. The number of patients indicated in the table is the number of patients at risk at the indicated time. Kidney International 2018 94, 983-992DOI: (10.1016/j.kint.2018.07.019) Copyright © 2018 International Society of Nephrology Terms and Conditions

Figure S1 Plasma zinc-alpha2-glycoprotein (ZAG) concentrations in patients on hemodialysis at baseline and 1 year later. Data are median (interquartile range). Note that no difference was found to be significant (P < 0.05). ln-transformed, log-transformed. Kidney International 2018 94, 983-992DOI: (10.1016/j.kint.2018.07.019) Copyright © 2018 International Society of Nephrology Terms and Conditions

Figure S2 Plasma zinc-alpha2-glycoprotein (ZAG) concentrations in patients on hemodialysis with a diagnostic of protein energy wasting (PEW). Data are median (interquartile range). Note that no difference was found to be significant (P < 0.05). ln-transformed, log-transformed. Kidney International 2018 94, 983-992DOI: (10.1016/j.kint.2018.07.019) Copyright © 2018 International Society of Nephrology Terms and Conditions

Figure S3 Kaplan-Meier estimates of cumulative survival of all patients according to plasma zinc-alpha2-glycoprotein concentration measured after 1 year of follow-up. Kidney International 2018 94, 983-992DOI: (10.1016/j.kint.2018.07.019) Copyright © 2018 International Society of Nephrology Terms and Conditions

Figure S4 (A–C) Receiver operating characteristic (ROC) curves of the ability of different traditional risk factor levels to predict all-cause mortality. (A) ROC curve comparing zinc-alpha2-glycoprotein (ZAG) level, N-terminal pro–brain natriuretic peptide (NT-proBNP) level, and Charlson score. (B) ROC curve comparing ZAG level, albumin level, and C-reactive protein (CRP) level. (C) ROC curve comparing ZAG level and Charlson score combined with Charlson score alone. (D–F) ROC curves of the ability of different traditional risk factor levels to predict cardiovascular events. (D) ROC curve comparing ZAG level, NT-proBNP level, and Charlson score. (E) ROC curve comparing ZAG level, albumin level, and CRP level. (F) ROC curve comparing ZAG level and Charlson score combined with Charlson score alone. Kidney International 2018 94, 983-992DOI: (10.1016/j.kint.2018.07.019) Copyright © 2018 International Society of Nephrology Terms and Conditions