PHL 313 (Lab. 6) Effect of Drugs on Rabbit’s Isolated Heart

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Presentation transcript:

PHL 313 (Lab. 6) Effect of Drugs on Rabbit’s Isolated Heart

Ringer’s Solution Sodium chloride Potassium chloride Glucose Sodium bicarbonate Calcium chloride Oxygen Temperature 37 C

Heart Rate (HR):Beats/min. Force of contraction. Parameters Heart Rate (HR):Beats/min. Force of contraction.

Normal Heart Rate 60-100 beats/ minute Tachycardia more than 100 beats/minute Bradycardia Less than 60 beats/ minute

Drugs Drug HR Force of contraction Epinephrine (beta receptor) increase Increase Norepinephrine (beta receptor) Propranolol ( beta blocker) Decrease Digoxin ( C.H.F) Procainamide ( anti arrhythmic) --------- KCL Verapamil (Ca. Ch. Blocker)