Individual Variation in Drug Responses Chapter 8 Individual Variation in Drug Responses

Individual Variation in Drug Responses Factors that influence drug responses are Body weight and composition Age Gender Pathophysiology

Drug Tolerance Decreased responsiveness to a drug due to repeated drug administration Three categories of drug tolerance Pharmacodynamic Metabolic Tachyphylaxis

Types of Drug Tolerance Pharmacodynamic tolerance Long-term administration Metabolic tolerance Accelerated drug metabolism Tachyphylaxis Repeated dosing over a short time

Bioavailability Ability of a drug to reach the systemic circulation from its site of administration Factors that influence bioavailability Product preparation Route of administration

Failure to Take Medicine as Prescribed Cooperative and accurate participation in one’s drug therapy Patient education Attitude toward taking medications Self-care capacity Finances

Failure to Take Medicine as Prescribed (cont.) Drug interactions Diet