Myosin Learns to Recruit AMPA Receptors

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Myosin Learns to Recruit AMPA Receptors Eran Perlson, Erika L.F. Holzbaur Cell Volume 135, Issue 3, Pages 414-415 (October 2008) DOI: 10.1016/j.cell.2008.10.013 Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 1 Myosin Vb-Dependent AMPA Receptor Trafficking during LTP During long-term potentiation (LTP), neuronal activation of NMDA receptors leads to a localized influx of Ca2+ at dendritic spines. This influx induces a Ca2+-dependent conformational change in myosin Vb (Wang et al., 2008). The unfolding of myosin Vb exposes a cargo-binding domain, which mediates the recruitment of the motor to the membrane-associated Rab11/effector complex on the recycling endosome. The activated myosin then drives the trafficking of AMPA receptors to synaptic sites, leading to the localized increase in AMPA receptor density characteristic of LTP. Cell 2008 135, 414-415DOI: (10.1016/j.cell.2008.10.013) Copyright © 2008 Elsevier Inc. Terms and Conditions