Figure 1 The current model of the pathogenesis of SLE

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CATEGORY: IMMUNE DYSFUNCTION Systemic Lupus Erythematosus (SLE) Angela Midgley, University of Liverpool, UK S YSTEMIC L UPUS E RYTHEMATOSUS © The copyright.

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Pathogenesis of systemic lupus erythematosus (SLE)

Systemic Lupus Erythematosus (SLE)

Pathogenesis of systemic lupus erythematosus (SLE)

Pathogenesis of systemic lupus erythematosus (SLE)

Systemic Lupus Erythematosus

Figure 3 The induction of anti-DNA antibodies by bacterial DNA

Figure 1 Lymphocytes during the disease

Figure 1 Role of innate lymphoid cells (ILCs) in steady state,

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of different experimental arthritis models

Figure 3 The adaptive and maladaptive energy matrices

Figure 5 Involvement of B cells in SLE

Figure 1 Historical evolution of the clinical classification and

Figure 1 Rheumatoid arthritis development over time in relation to the level of inflammation Figure 1 | Rheumatoid arthritis development over time in relation.

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 2 Proinflammatory mechanisms in CKD

Figure 1 Factors underlying metabolic alterations in osteoarthritis

Figure 1 Induction of immune tolerance

Figure 2 Risk factors for sarcopenia

Figure 3 Proposed mechanisms underlying the links

Figure 2 Heat map of targeted therapies in autoimmune diseases

Figure 5 Defects in the JAK–STAT signalling pathway

Figure 1 Organs involved in coeliac-disease-associated autoimmunity

Figure 2 Targeted versus untargeted metabolomics approaches

Figure 1 Metabolic profiling as a tool for studying rheumatic diseases

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Figure 4 Antinuclear antibodies and disease activity in SLE

Figure 3 Transcriptome studies performed in the target

Figure 2 Shared genetic loci in systemic autoimmune diseases

Figure 7 Defects in apoptosis

Figure 3 Nucleic acid sensors in SLE

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Figure 1 Location of HLA variants known to be associated

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Figure 1 The central role of chronic prostate

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Nat. Rev. Rheumatol. doi: /nrrheum

Figure 4 Approaches to targeting inhibitory immune receptors

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Figure 2 Overlap of associated loci among five rheumatic diseases

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Nat. Rev. Rheumatol. doi: /nrrheum

Figure 3 Statistical approaches for the analysis of metabolomic data

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Figure 1 Environmental factors contributing to IBD pathogenesis

Figure 3 Multi-hit model for autoimmune diseases

Immunopathogenesis of Rheumatoid Arthritis

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Figure 1 Evolution of multiple sclerosis

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Nat. Rev. Rheumatol. doi: /nrrheum

Figure 1 Treat to target, remission and low disease activity in SLE

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Figure 1 Sequence of events in the development of autoimmune nephritis

Figure 1 Chronic inflammation and DNA damage in people with SLE

Figure 3 Nuclear-penetrating autoantibodies and synthetic lethality

Figure 2 Lifelong influences on the gut microbiome from

primary Sjögren syndrome

Figure 2 Cellular contributions to the development of SLE

Figure 2 Phenotypes of osteoarthritis

Deficiency of TLR9 promotes more severe renal inflammation in imiquimod-induced autoimmunity. Deficiency of TLR9 promotes more severe renal inflammation.

Figure 1 Patterns of joint and organ involvement in rheumatic disease

Figure 1 The role of macrophages in RA

SLE: the many players involved in systemic autoimmunity and tissue destruction. SLE: the many players involved in systemic autoimmunity and tissue destruction.

Systemic autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and systemic sclerosis (SSc) cause immune-mediated.

Nat. Rev. Rheumatol. doi: /nrrheum

Jacques Banchereau, Virginia Pascual Immunity

Figure 2 Involvement of plasmacytoid dendritic cells

Presentation transcript:

Figure 1 The current model of the pathogenesis of SLE Figure 1 | The current model of the pathogenesis of SLE. The progression of systemic lupus erythematosus (SLE) can be divided into discrete stages. Environmental and genetic factors contribute to the development of disease. Triggers such as infection can elicit autoimmunity, but the elements that drive a sustained loss of tolerance and spreading of autoimmunity are poorly understood. Epigenetic changes, immune-complex deposition and autoantibody-mediated tissue damage can drive chronic inflammation and irreversible damage in end organs. IFN, interferon. Tsokos, G. C. et al. (2016) New insights into the immunopathogenesis of systemic lupus erythematosus Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2016.186