Joseph H. Antin, Allen R. Chen, Daniel R. Couriel, Vincent T

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Presentation transcript:

Novel approaches to the therapy of steroid-resistant acute graft-versus-host disease Joseph H. Antin, Allen R. Chen, Daniel R. Couriel, Vincent T. Ho, Richard A. Nash, Daniel Weisdorf Biology of Blood and Marrow Transplantation Volume 10, Issue 10, Pages 655-668 (October 2004) DOI: 10.1016/j.bbmt.2004.07.007 Copyright © 2004 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Available agents targeting human IL-2R: agents targeting activated T cells through the IL-2 receptor. For the 3 monoclonal antibodies, red indicates murine structural elements, and red is the humanized portion. For denileukin diftitox, gray represents the IL-2 molecule, and black represents the diphtheria toxin moiety. Comp/ADCC, complement activation/antibody-dependent cellular cytotoxicity; RE-blockade, reticuloendothelial blockade. Figure is adapted courtesy of Dr. Fred LeMaistre. Biology of Blood and Marrow Transplantation 2004 10, 655-668DOI: (10.1016/j.bbmt.2004.07.007) Copyright © 2004 American Society for Blood and Marrow Transplantation Terms and Conditions