Inflammatory response, immunosuppression, and cancer recurrence after perioperative blood transfusions J.P. Cata, H. Wang, V. Gottumukkala, J. Reuben,

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Inflammatory response, immunosuppression, and cancer recurrence after perioperative blood transfusions J.P. Cata, H. Wang, V. Gottumukkala, J. Reuben, D.I. Sessler British Journal of Anaesthesia Volume 110, Issue 5, Pages 690-701 (May 2013) DOI: 10.1093/bja/aet068 Copyright © 2013 The Author(s) Terms and Conditions

Fig 1 The figure illustrates the interaction between cellular and humoral responses against cancer cells. The cellular immune response is composed of Th1 and Tc1 (anti-tumour) and Th2 and Tc2 (pro-tumoral) lymphocytes. Similarly, the cytokine immune response is accomplished by Th1 (IL-2, IL-12, IFN-γ, and TNF-γ) predominantly antitumour cytokines; in contrast, the Th2 cytokines (IL-4, IL-5, IL-6, and IL-10) have mainly pro-tumour actions. British Journal of Anaesthesia 2013 110, 690-701DOI: (10.1093/bja/aet068) Copyright © 2013 The Author(s) Terms and Conditions