Foxp3 and Natural Regulatory T Cells

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Foxp3 and Natural Regulatory T Cells Fred Ramsdell Immunity Volume 19, Issue 2, Pages 165-168 (August 2003) DOI: 10.1016/S1074-7613(03)00207-3

Figure 1 A Potential Model for Foxp3 in TR Development Foxp3 expression occurs during thymic selection as a consequence of affinity for self-ligand or specific antigen-bearing cells. Continued expression of Foxp3 is required for natural TR function in the periphery, and may be involved in the generation of induced TR cells following tolerogenic stimulation of T cells. Immunity 2003 19, 165-168DOI: (10.1016/S1074-7613(03)00207-3)