Synergistic Immunosuppression Caused by High-Dose Methylprednisolone and Cardiopulmonary Bypass Hisanori Mayumi, MD, Qui-Wei Zhang, MD, Atsuhiro Nakashima,

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Presentation transcript:

Synergistic Immunosuppression Caused by High-Dose Methylprednisolone and Cardiopulmonary Bypass Hisanori Mayumi, MD, Qui-Wei Zhang, MD, Atsuhiro Nakashima, MD, Munetaka Masuda, MD, Hiroyuki Kohno, MD, Yoshito Kawachi, MD, Hisataka Yasui, MD The Annals of Thoracic Surgery Volume 63, Issue 1, Pages 129-137 (January 1997) DOI: 10.1016/S0003-4975(96)00682-0

Fig. 1 Changes in (a) white blood cell count, (b) lymphocyte count, (c) C-reactive protein level, and (d) body weight. (Ad. = admission; C-group = control group; CPB = cardiopulmonary bypass; POD = postoperative day; S-group = steroid group; ∗p < 0.05 by Student’s t test between groups; ∗∗p < 0.01 by t test; ∗∗∗p < 0.001 by t test.) The Annals of Thoracic Surgery 1997 63, 129-137DOI: (10.1016/S0003-4975(96)00682-0)

Fig. 2 Changes in (a) CD3+ (T) cells, (b) CD20+(B) cells, and (c) CD16+(NK) cells. (Ad. = admission; C-group = control group; CPB = cardiopulmonary bypass; POD = postoperative day; S-group = steroid group; ∗p < 0.05 by Student’s t test between groups; ∗∗p < 0.01 by t test.) The Annals of Thoracic Surgery 1997 63, 129-137DOI: (10.1016/S0003-4975(96)00682-0)

Fig. 3 Changes in (a) CD4+ (helper/inducer T) cells, (b) CD8+ (killer/suppressor T) cells, and (c) CD4/CD8 ratio. (Ad. = admission; C-group = control group; CPB = cardiopulmonary bypass; POD = postoperative day; S-group = steroid group; ∗p < 0.05 by Student’s t test between groups; ∗∗p < 0.01 by t test.) The Annals of Thoracic Surgery 1997 63, 129-137DOI: (10.1016/S0003-4975(96)00682-0)

Fig. 4 Changes in (a) phytohemagglutinin (PHA) response, (b) interleukin-2 (IL-2) production, and (c) natural killer (NK) cell activity. (Ad. = admission; C-group = control group; CPB = cardiopulmonary bypass; POD = postoperative day; S-group = steroid group; spont. = spontaneous release; ∗p < 0.05 by Student’s t test between groups; ∗∗p < 0.01 by t test; ∗∗∗p < 0.001 by t test.) The Annals of Thoracic Surgery 1997 63, 129-137DOI: (10.1016/S0003-4975(96)00682-0)

Fig. 5 Hemodynamics and pulmonary function: (a) cardiac index and (b) arterial oxygen tension (PaO2) under pure oxygen. (CPB = cardiopulmonary bypass; C-group = control group; FiO2 = inspired oxygen fraction; POD = postoperative day; S-group = steroid group.) The Annals of Thoracic Surgery 1997 63, 129-137DOI: (10.1016/S0003-4975(96)00682-0)

Fig. 6 Metabolism during operations: (a) lactate and (b) serum glucose levels. (C-group = control group; CPB = cardiopulmonary bypass; Max. = maximum; op. = operation; S-group = steroid group; ∗p < 0.05 by Student’s t test between groups; ∗∗p < 0.01 by t test.) The Annals of Thoracic Surgery 1997 63, 129-137DOI: (10.1016/S0003-4975(96)00682-0)