Anne F. Nielsen, Jiradet Gloggnitzer, Javier Martinez Molecular Cell

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MicroRNAs Cross the Line: The Battle for mRNA Stability Enters the Coding Sequence Anne F. Nielsen, Jiradet Gloggnitzer, Javier Martinez Molecular Cell Volume 35, Issue 2, Pages 139-140 (July 2009) DOI: 10.1016/j.molcel.2009.07.006 Copyright © 2009 Elsevier Inc. Terms and Conditions

Figure 1 CRD-BP and miRNA-183 Act Antagonistically in the CDS to Control the Stability of βTrCP1 mRNA (A) In complex with Ago2, miR-183 binds the βTrCP1 mRNA in the CDS and triggers degradation. (B) CRD-BP could displace miR-183 and Ago2 by competing for a partially overlapping binding site. (C) Alternatively, CRD-BP may alter the secondary structure of the βTrCP1 mRNA, thereby rendering the miR-183-binding site inaccessible. Molecular Cell 2009 35, 139-140DOI: (10.1016/j.molcel.2009.07.006) Copyright © 2009 Elsevier Inc. Terms and Conditions