Stepholidine is a promising anti-psychotic

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Presentation transcript:

Stepholidine is a promising anti-psychotic Stepholidine is a promising anti-psychotic. This molecule was isolated from a Chinese herb. It is a D1 dopamine receptor agonist, but a D2 dopamine receptor antagonist. Cheng, Jian-Jun; Yang, Yu-She. Enantioselective Total Synthesis of (-)-(S)-Stepholidine. Journal of Organic Chemistry (2009), 74(23), 9225-9228.

Bishler-Napieralski Reaction The Bishler-Napieralski Reaction is an electrophilic aromatic substitution whereby a suitably placed amide is transformed into an electrophile through the action of phosphorus oxychloride.

Asymmetric Transfer Hydrogenation