Tacrolimus ointment in the treatment of dirty neck lesions in atopic dermatitis  Kayako Hira, MD, Yasushi Suga, MD, PhD, Tomoyuki Monma, Kouichi Mitsuishi,

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Tacrolimus ointment in the treatment of dirty neck lesions in atopic dermatitis  Kayako Hira, MD, Yasushi Suga, MD, PhD, Tomoyuki Monma, Kouichi Mitsuishi, MD, Hideoki Ogawa, MD, PhD  Journal of the American Academy of Dermatology  Volume 52, Issue 4, Pages 720-722 (April 2005) DOI: 10.1016/j.jaad.2004.10.860 Copyright © 2005 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Clinical manifestations of the “dirty neck” lesion for the representative case (case 1) were photographed at baseline (a) and after 4 months of treatment (d). The diffuse erythema and dark brown pigmentation decreased after treatment. b and e, Extracted blue signal image of the pigmentary spot images before and after treatment, respectively. c and f, Exchanged binary data image from the intensity of blue signal (0-255) before and after treatment, respectively. The decrease in the dark brown zebra-type pigmentation could also be picked up and measured by the computer. Arrows indicate the representative area where the reticulate pigmentation appeared to be separated and divided into smaller fragments as the lesions improved. Journal of the American Academy of Dermatology 2005 52, 720-722DOI: (10.1016/j.jaad.2004.10.860) Copyright © 2005 American Academy of Dermatology, Inc. Terms and Conditions