Sustained HIV infection with CXCR4-tropic NL4-3 in MISTRG and MITRG mice. Sustained HIV infection with CXCR4-tropic NL4-3 in MISTRG and MITRG mice. Analogously.

Slides:

Advertisements

Similar presentations

High-dimensional analysis of lymphoid CD4+ T cells identified distinct TFH cell subsets in HIV+ patients and HCs. High-dimensional analysis of lymphoid.

Advertisements

Dominant IL-21 expression in TFH cells correlate with B cell pathology in HIV-infected LNs. Dominant IL-21 expression in TFH cells correlate with B cell.

Blood T-cell receptor diversity decreases during the course of HIV infection, but the potential for a diverse repertoire persists by Paul D. Baum, Jennifer.

Joseph C. Mudd, Jason M. Brenchley Immunity

PbA‐specific CD4 T‐cell responses are maximal at day 6 post‐pRBC infection PbA‐specific CD4 T‐cell responses are maximal at day 6 post‐pRBC infection Proportion.

Quantitative analysis of the latent reservoir during treatment interruption. Quantitative analysis of the latent reservoir during treatment interruption.

Volume 145, Issue 5, Pages (November 2013)

Depletion of CD169+ cells leads to increased expression of CD25 on enterotoxin A–specific Vβ3+ T cells. Depletion of CD169+ cells leads to increased expression.

Sunitinib plus rMVA–CEA–TRICOM vaccine decreased tumor burden and increased intratumoral infiltration of T lymphocytes in the MC38-CEA colon carcinoma.

Viral load and CD4+ T cells in CD8+ T cell–depleted YU-2–infected MISTRG mice. Viral load and CD4+ T cells in CD8+ T cell–depleted YU-2–infected MISTRG.

Changes in splenic CD4+ and CD8+ T cell subsets during acute and chronic HIV infection in MISTRG mice. Changes in splenic CD4+ and CD8+ T cell subsets.

Smaller T cell zone FRC areas in aged spleens.

Serum levels of IL-21 are elevated in a subset of patients with IM

Volume 21, Issue 12, Pages (December 2017)

HuR physically interacts with the Il2ra 3′UTR mRNA and enhances its translational efficiency in activated CD4+ T cells. HuR physically interacts with the.

Specific depletion of TFH and LCMV-specific CD4 T cells.

CD160−/− IELs have a defect in granzyme B production during L

CD8α+ DC-deficient mice are highly susceptible to Lm infection in the absence of CD169+ macrophages. CD8α+ DC-deficient mice are highly susceptible to.

Volume 153, Issue 4, Pages (May 2013)

Altered cytokine production by Klrk1−/− NOD CTL

Copy number estimation for Bacillus anthracis plasmids pXO1 and pXO2.

Specific depletion of CD4-DTR–derived CD4 T cells.

CD160−/− mice have impaired clearance of oral L

CCR2+ monocytes are a relevant source of type I IFN in response to Af.

Human T cells undergoing apoptosis and necroptosis release mitochondria, and apoptotic mitochondria recruit neutrophils. Human T cells undergoing apoptosis.

Immunological phenotypes of CD4+ T cells preferentially infected by HIV. PBMCs exposed to HIV-1BaL (MOI 0.01) were cultured for 10 d. Immunological phenotypes.

CD169+ macrophages mediate Lm translocation to the splenic T cell zones. CD169+ macrophages mediate Lm translocation to the splenic T cell zones. (A) Confocal.

STAT3 regulates GC and plasma cell IgE class switching in B cells.

Immune cell populations, activation, and NKG2D and H60a expression in the spleen of untreated and antibiotic-treated Klrk1+/+ and Klrk1−/− NOD mice. Immune.

Volume 158, Issue 5, Pages (August 2014)

Extracellular mitochondria cause neutrophil recruitment.

IBD development correlates with peripheral T cell activation in DNR mice. IBD development correlates with peripheral T cell activation in DNR mice. (A)

“Responders” and “off-responders” proportions.

Distribution of splenic T cells, B cells, and NK cells in NSG hL-7xhIL-15 humanized mice. Distribution of splenic T cells, B cells, and NK cells in NSG.

IL-27 contributes to IR expression by lung T cells during toxoplasmosis. IL-27 contributes to IR expression by lung T cells during toxoplasmosis. (A) Il27p28-GFP.

Human T cells undergoing apoptosis and necroptosis release mitochondria, and apoptotic mitochondria recruit neutrophils. Human T cells undergoing apoptosis.

The mucosal environment regulates CD160 expression on IELs

Comparison of male and female CD8+ T cells primed with different amounts of cognate Ag. (A) Schematic of experimental design: 1 × 104 gBT-I CD8+ T cells.

AhR activation reduces lung DC gene and surface expression of DC-SIGN.

CD160 on CD8+ T cells is required for optimal clearance of L

CXCR5+/+ TFH cells are essential for the generation of LCMV-neutralizing antibodies and clearance of a persistent LCMV infection. CXCR5+/+ TFH cells are.

Fig. 1. MSCs undergo in vivo apoptosis after infusion without affecting immunosuppression. MSCs undergo in vivo apoptosis after infusion without affecting.

Observed (symbols) and predicted (solid lines, eq

CD4-TEMRA cells are heterogeneous across donors.

CD8α+, CD8α−, and MoDCs from NOD.hCD205 mice express hCD205.

CD25+ proliferation and suppression are independent functional variables in type 1 diabetes. CD25+ proliferation and suppression are independent functional.

mRNA adenosine-to-inosine editing increases under DR.

Figure 1. Longitudinal measures of HIV persistence and immunologic phenotype/function during anti-PD-1 therapy are ... Figure 1. Longitudinal measures.

CD27+ expression correlates with robust Ag-specific responses to M

The CDR3 region of the Vγ1.1 chain is involved in ligand recognition by the Vγ1.1 Vδ6.3 TCR+ hybridomas. The CDR3 region of the Vγ1.1 chain is involved.

Estradiol but not progesterone increases overall excitability and burst events in AVPV kisspeptin neurons. Estradiol but not progesterone increases overall.

Spontaneous and strong Tfh cell but not Tfr cell development in IL-2 KO mice. Spontaneous and strong Tfh cell but not Tfr cell development in IL-2 KO mice.

Frequency and kinetics of killer cell apoptosis are dependent on functional conjugations with multiple NALM-6 tumor cells. Frequency and kinetics of killer.

CD25 surface expression and TCR signal strength predict T helper differentiation and memory potential of early effector T cells in vivo. CD25 surface expression.

Loss of Tfh and GC B cells in 2KO-Bcl6TC mice.

Overexpression of IL-27 upregulates expression of multiple IR by T cells in vivo. Overexpression of IL-27 upregulates expression of multiple IR by T cells.

Tfr cells respond better to immunization with self-antigens than with foreign antigens. Tfr cells respond better to immunization with self-antigens than.

Spatial frequency preferences of contralateral responses is higher than ipsilateral responses in AAV-SynGCaMP6s-injected mice. Spatial frequency preferences.

Higher spatial frequency tuning of the contralateral responses also found in anesthetized animals. Higher spatial frequency tuning of the contralateral.

Sustained T follicular helper cell response is essential for control of chronic viral infection by Ute Greczmiel, Nike Julia Kräutler, Alessandro Pedrioli,

CD25 expression predicts effector and memory differentiation.

Fig. 4 Dox-CBD-SA treatment shows reduced toxicity.

CD4-CTL effectors share TCR clonotypes with CD4-CTL precursors.

Mice with a B cell–specific loss of Ets1 have reduced marginal zone B cells and increased ASCs. (A) Flow cytometry analysis of CD21 versus CD23 in gated.

Mice with a B cell–specific deletion of Ets1 have increased memory phenotype B cells but no increase in switching to IgG1. Mice with a B cell–specific.

Human basophils are unresponsive to contact-dependent or contact-independent inhibition by Tregs. Human basophils are unresponsive to contact-dependent.

Correlations between APOBEC expression and immune cell markers across 22 cancer types. Correlations between APOBEC expression and immune cell markers across.

Mice with a B cell–specific deletion of Ets1 do not have increased CD4+ T cell activation. Mice with a B cell–specific deletion of Ets1 do not have increased.

Surface expression of chemokine receptors on M

Presentation transcript:

Sustained HIV infection with CXCR4-tropic NL4-3 in MISTRG and MITRG mice. Sustained HIV infection with CXCR4-tropic NL4-3 in MISTRG and MITRG mice. Analogously to YU-2 infection, mice were infected with 200,000 TCID50 of NL4-3. (A) HIV RNA copy numbers were measured in the plasma in MISTRG mice (HIV+ = red circles) and MITRG mice (HIV+ = blue squares). (B) Percentages of CD3+ cells in uninfected as well as in HIV-infected MISTRG and MITRG mice (HIV+ MISTRG mice = red circles; HIV− MISTRG mice = gray circles; HIV+ MITRG mice = blue squares; HIV− MITRG mice = gray squares). (C and D) Spearman correlation between the percentages of CD4+CD38+HLA-DR+ cells (C) and CD8+CD38+HLA-DR+ cells (D) (of hCD45+ cells) and HIV RNA copies per milliliter in plasma at 4 wk p.i. (E) Distribution of different cell types in the spleen at euthanasia for uninfected mice (MISTRG, n = 3; MITRG, n = 9) and infected mice (MISTRG, n = 8; MITRG, n = 3) at 12 and 20 wk p.i. (F) Frequencies of activated CD8+ T cells of hCD45+ cells in spleen. All data are mean ± SEM. Statistical differences between groups at different times were calculated by the two-tailed Mann–Whitney U test (A and B) and the Kruskal–Wallis test with the Dunn multiple-comparison test (E and F). *p < 0.05. Sandra Ivic et al. ImmunoHorizons 2017;1:162-175 Copyright © 2017 The Authors