Cellular and mediator responses twenty-four hours after local endobronchial allergen challenge of asthmatic airways Anthony J. Frew, MD, Johanne St-Pierre,

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Cellular and mediator responses twenty-four hours after local endobronchial allergen challenge of asthmatic airways Anthony J. Frew, MD, Johanne St-Pierre, PhD, Luis M. Teran, MD, PhD, Alexandre Trefilieff, PhD, Jacqueline Madden, MPhil, Diego Peroni, MD, Kathleen M. Bodey, BSc, Andrew F. Walls, PhD, Peter H. Howarth, DM, Mary P. Carroll, MD, Stephen T. Holgate, MD Journal of Allergy and Clinical Immunology Volume 98, Issue 1, Pages 133-143 (July 1996) DOI: 10.1016/S0091-6749(96)70235-X Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 1 CD3+ T-cell numbers in blood before and 24 hours after challenge (A) and in the BAL samples obtained 24 hours after allergen or saline segmental challenge (B). Journal of Allergy and Clinical Immunology 1996 98, 133-143DOI: (10.1016/S0091-6749(96)70235-X) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 1 CD3+ T-cell numbers in blood before and 24 hours after challenge (A) and in the BAL samples obtained 24 hours after allergen or saline segmental challenge (B). Journal of Allergy and Clinical Immunology 1996 98, 133-143DOI: (10.1016/S0091-6749(96)70235-X) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 2 Numbers of mast cells, eosinophils, and neutrophils per square millimeter in bronchial submucosa after allergen or saline challenge. Journal of Allergy and Clinical Immunology 1996 98, 133-143DOI: (10.1016/S0091-6749(96)70235-X) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 2 Numbers of mast cells, eosinophils, and neutrophils per square millimeter in bronchial submucosa after allergen or saline challenge. Journal of Allergy and Clinical Immunology 1996 98, 133-143DOI: (10.1016/S0091-6749(96)70235-X) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 2 Numbers of mast cells, eosinophils, and neutrophils per square millimeter in bronchial submucosa after allergen or saline challenge. Journal of Allergy and Clinical Immunology 1996 98, 133-143DOI: (10.1016/S0091-6749(96)70235-X) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 3 Number of cells per square millimeter expressing CD3, CD4, CD8, or CD25 in bronchial submucosa after allergen or saline challenge. Journal of Allergy and Clinical Immunology 1996 98, 133-143DOI: (10.1016/S0091-6749(96)70235-X) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 3 Number of cells per square millimeter expressing CD3, CD4, CD8, or CD25 in bronchial submucosa after allergen or saline challenge. Journal of Allergy and Clinical Immunology 1996 98, 133-143DOI: (10.1016/S0091-6749(96)70235-X) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 3 Number of cells per square millimeter expressing CD3, CD4, CD8, or CD25 in bronchial submucosa after allergen or saline challenge. Journal of Allergy and Clinical Immunology 1996 98, 133-143DOI: (10.1016/S0091-6749(96)70235-X) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 3 Number of cells per square millimeter expressing CD3, CD4, CD8, or CD25 in bronchial submucosa after allergen or saline challenge. Journal of Allergy and Clinical Immunology 1996 98, 133-143DOI: (10.1016/S0091-6749(96)70235-X) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 4 Bronchial biopsy specimens showing endothelial staining for the adhesion molecules P-selectin (A) and ICAM-1 (B) 24 hours after local allergen challenge. (Original magnification ×400.) Journal of Allergy and Clinical Immunology 1996 98, 133-143DOI: (10.1016/S0091-6749(96)70235-X) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 4 Bronchial biopsy specimens showing endothelial staining for the adhesion molecules P-selectin (A) and ICAM-1 (B) 24 hours after local allergen challenge. (Original magnification ×400.) Journal of Allergy and Clinical Immunology 1996 98, 133-143DOI: (10.1016/S0091-6749(96)70235-X) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 5 Percentage of small blood vessels expressing ICAM-1, P-selectin, E-selectin, or VCAM-1 and the numbers of cells per square millimeter expressing LFA-1 or VLA-4 in the bronchial submucosa after allergen or saline challenge. Journal of Allergy and Clinical Immunology 1996 98, 133-143DOI: (10.1016/S0091-6749(96)70235-X) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 5 Percentage of small blood vessels expressing ICAM-1, P-selectin, E-selectin, or VCAM-1 and the numbers of cells per square millimeter expressing LFA-1 or VLA-4 in the bronchial submucosa after allergen or saline challenge. Journal of Allergy and Clinical Immunology 1996 98, 133-143DOI: (10.1016/S0091-6749(96)70235-X) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 5 Percentage of small blood vessels expressing ICAM-1, P-selectin, E-selectin, or VCAM-1 and the numbers of cells per square millimeter expressing LFA-1 or VLA-4 in the bronchial submucosa after allergen or saline challenge. Journal of Allergy and Clinical Immunology 1996 98, 133-143DOI: (10.1016/S0091-6749(96)70235-X) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 5 Percentage of small blood vessels expressing ICAM-1, P-selectin, E-selectin, or VCAM-1 and the numbers of cells per square millimeter expressing LFA-1 or VLA-4 in the bronchial submucosa after allergen or saline challenge. Journal of Allergy and Clinical Immunology 1996 98, 133-143DOI: (10.1016/S0091-6749(96)70235-X) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 5 Percentage of small blood vessels expressing ICAM-1, P-selectin, E-selectin, or VCAM-1 and the numbers of cells per square millimeter expressing LFA-1 or VLA-4 in the bronchial submucosa after allergen or saline challenge. Journal of Allergy and Clinical Immunology 1996 98, 133-143DOI: (10.1016/S0091-6749(96)70235-X) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 5 Percentage of small blood vessels expressing ICAM-1, P-selectin, E-selectin, or VCAM-1 and the numbers of cells per square millimeter expressing LFA-1 or VLA-4 in the bronchial submucosa after allergen or saline challenge. Journal of Allergy and Clinical Immunology 1996 98, 133-143DOI: (10.1016/S0091-6749(96)70235-X) Copyright © 1996 Mosby, Inc. Terms and Conditions