Reduction of Sample Heterogeneity through Use of Population Substructure: An Example from a Population of African American Families with Sarcoidosis

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Reduction of Sample Heterogeneity through Use of Population Substructure: An Example from a Population of African American Families with Sarcoidosis Cheryl L. Thompson, Benjamin A. Rybicki, Michael C. Iannuzzi, Robert C. Elston, Sudha K. Iyengar, Courtney Gray-McGuire The American Journal of Human Genetics Volume 79, Issue 4, Pages 606-613 (October 2006) DOI: 10.1086/507847 Copyright © 2006 The American Society of Human Genetics Terms and Conditions

Figure 1 Results of stratified linkage analysis. In each plot, the solid line represents the results from the original (full sample) linkage analysis, plotted as the −log(P value) versus the distance from the first marker. The dashed line represents the results from S1. The dotted line represents the results from S2. The horizontal lines represent P values of 1.0×10−3 (lower) and 2.2×10−5 (upper). The values to the right of the plots represent the corresponding LOD scores. The American Journal of Human Genetics 2006 79, 606-613DOI: (10.1086/507847) Copyright © 2006 The American Society of Human Genetics Terms and Conditions