Zebrafish Reel in Phenotypic Suppressors of Autism

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Zebrafish Reel in Phenotypic Suppressors of Autism Jakob Biran, Gil Levkowitz Neuron Volume 89, Issue 4, Pages 673-675 (February 2016) DOI: 10.1016/j.neuron.2016.02.005 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Behavioral Drug-Effect Profiling Reveals Phenotypic Suppressors of cntnap2 Mutant (A) The CNTNAP2 gene is linked to ASD in human. Zebrafish cntnap2 mutants display heightened nighttime activity (Hoffman et al., 2016). (B) Quantitative behavioral profiling of wild-type zebrafish larvae treated with a collection of psychoactive compounds identifies small molecules that phenocopy the cntnap2 mutant phenotype (correlating) as well as compounds eliciting a behavioral signature opposite to that of mutant larvae (anti-correlating). This screen showed that molecules with estrogen-like activity suppress the cntnap2 mutant phenotype. Neuron 2016 89, 673-675DOI: (10.1016/j.neuron.2016.02.005) Copyright © 2016 Elsevier Inc. Terms and Conditions