Volume 4, Issue 1, Pages (January 2018)

Slides:

Advertisements

Similar presentations

Structure of a Ubiquitin E1-E2 Complex: Insights to E1-E2 Thioester Transfer Shaun K. Olsen, Christopher D. Lima Molecular Cell Volume 49, Issue 5, Pages.

Advertisements

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell

The Metabolic Basis of Pulmonary Arterial Hypertension Gopinath Sutendra, Evangelos D. Michelakis Cell Metabolism Volume 19, Issue 4, Pages (April.

Adaptation to Natural Binocular Disparities in Primate V1 Explained by a Generalized Energy Model Ralf M. Haefner, Bruce G. Cumming Neuron Volume 57, Issue.

Kent O. Kirlikovali, Alexander M. Spokoyny Chem

A Reliability Look at Energy Development

Influenza A Virus Lures Autophagic Protein LC3 to Budding Sites

“Seeing” the Invisibles at the Single-Molecule Level

A New Dimension for Low-Dimensional Carbon Nanostructures

Quentin Michaudel, Brett P. Fors Chem

Reaction: A New Genesis for Origins Research?

Foundations for Directed Alkaloid Biosynthesis

Robert S. Jordan, Yves Rubin Chem

Ubiquitination Accomplished: E1 and E2 Enzymes Were Not Necessary

Luc Neuville, Philippe Dauban Chem

Kent O. Kirlikovali, Alexander M. Spokoyny Chem

Volume 3, Issue 5, Pages (November 2017)

Volume 3, Issue 2, Pages (August 2017)

Direct Growth of Well-Aligned MOF Arrays onto Various Substrates

Phenol Functionalization Inspired by Melanogenesis

Synthesis of Acrylic Acid Derivatives from CO2 and Ethylene

Brett A. Helms, Thomas P. Russell Chem

Lotta Turunen, Ulrike Warzok, Christoph A. Schalley, Kari Rissanen

Volume 1, Issue 2, Pages (August 2016)

Screening Solvent Effects in Anion Recognition

Volume 26, Issue 2, Pages (February 2018)

Twisted Cycloalkynes and Remote Activation of “Click” Reactivity

Volume 14, Issue 1, Pages (January 2007)

The Role of the RNAi Machinery in Heterochromatin Formation

Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex

MicroRNAs and Viral Infection

Yuping Wang, J. Fraser Stoddart Chem

A Method that Will Captivate U

Volume 21, Issue 5, Pages (March 2006)

Bio-inspired Self-Healing Electrolytes for Li-S Batteries

Fluorescent Probes Containing Selenium as a Guest or Host

Igor V. Alabugin, Trevor Harris Chem

Aromatics from Syngas: CO Taking Control

Foundations for Directed Alkaloid Biosynthesis

Chasing Endogenous Receptor Dynamics by Chemical Protein Labeling

Volume 4, Issue 4, Pages (April 2018)

Transforming CO2 by Stabilizing the Labile Product

Twisted Cycloalkynes and Remote Activation of “Click” Reactivity

Ubiquitin Makes Its Mark on Immune Regulation

Sensing Very Weak Strains at the Single-Molecule Scale

Structural Basis of cis- and trans-Combretastatin Binding to Tubulin

Xinxin Gao, Rami N. Hannoush Cell Chemical Biology

Click Chemistry in Complex Mixtures: Bioorthogonal Bioconjugation

Richard Stones, Alexandra Olaya-Castro Chem

The Elusive Nature of Excited States in Singlet Fission Materials

Hongcai Gao, Sen Xin, John B. Goodenough Chem

Philip Cohen, Marianna Tcherpakov Cell

Xiang-Yu Chen, Dieter Enders Chem

Volume 3, Issue 1, Pages 8-10 (July 2017)

Reaction: Chemistry Driven by the Harsh Space Environment

Volume 4, Issue 3, Pages (March 2018)

Volume 61, Issue 2, Pages (January 2016)

Volume 2, Issue 6, Pages (June 2017)

High-Performance Conjugated Polymer Photosensitizers

Array-Based Sensing of Whisky: A Whiff of the Spirit World

Greater Porosity with Redox Reaction Speeds Up MOF Color Change

Facile Synthesis of Multi-shelled ZnS-CdS Cages with Enhanced Photoelectrochemical Performance for Solar Energy Conversion Peng Zhang, Bu Yuan Guan,

Chapter 20 Assisted Reproductive Technologies

David Hubel and Torsten Wiesel

Assembling Halogen-Bonded Capsules via Cation Exchange

Helium Shows New Chemistry Not Seen Anywhere Else

Reaction: Synthesis in Drug Discovery, the Short and Long of It

Volume 2, Issue 5, Pages (May 2017)

Metal-Organic Polyhedra to Control the Conductance of a Lipid Membrane

Volume 3, Issue 5, Pages (November 2017)

Presentation transcript:

Volume 4, Issue 1, Pages 124-137 (January 2018) Light Harvesting for Rapid and Selective Reactions: Click Chemistry with Strain- Loadable Alkenes Kamaljeet Singh, Christopher J. Fennell, Evangelos A. Coutsias, Reza Latifi, Steve Hartson, Jimmie D. Weaver Chem Volume 4, Issue 1, Pages 124-137 (January 2018) DOI: 10.1016/j.chempr.2017.11.007 Copyright © 2017 Elsevier Inc. Terms and Conditions

Chem 2018 4, 124-137DOI: (10.1016/j.chempr.2017.11.007) Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Conjugation Strategies Chem 2018 4, 124-137DOI: (10.1016/j.chempr.2017.11.007) Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 2 Demonstration of Biotin Conjugation to Insulin via Strain-Loadable Alkene Coupling There are three modifiable sites on the insulin structure highlighted in red: the N termini on the A and B strands and the lysine residue on the B strand. The matrix-assisted laser desorption/ionization spectra on the right show modification and identification of two variants of the monoconjugated protein. Chem 2018 4, 124-137DOI: (10.1016/j.chempr.2017.11.007) Copyright © 2017 Elsevier Inc. Terms and Conditions

Scheme 1 The Development of the Molecular Mousetrap (A) First effort to capture photochemical energy as ring strain. (B) Attempts to chemically capture strained alkenes. Significant dimerization was observed for entries 3 and 4; see Supplemental Information for details. (C) Calculated torsion angle energy landscapes about the ring alkene bonds in (left) PC7 and (right) BC7. (D) Reaction results for BC6, BC7, and BC8 triazoline formation. (E) Two views of the crystal structure of the major product, showing the trans-ring fusion. Chem 2018 4, 124-137DOI: (10.1016/j.chempr.2017.11.007) Copyright © 2017 Elsevier Inc. Terms and Conditions

Scheme 2 Visible-Light-Mediated [3 + 2] Cycloaddition of Benzofused Cycloheptenes and Azides Chem 2018 4, 124-137DOI: (10.1016/j.chempr.2017.11.007) Copyright © 2017 Elsevier Inc. Terms and Conditions

Scheme 3 Reaction Outcome in the Presence of Various Fluorophores Chem 2018 4, 124-137DOI: (10.1016/j.chempr.2017.11.007) Copyright © 2017 Elsevier Inc. Terms and Conditions