BTLA+ Dendritic Cells: The Regulatory T Cell Force Awakens

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BTLA+ Dendritic Cells: The Regulatory T Cell Force Awakens Thomas Simon, Jonathan S. Bromberg Immunity Volume 45, Issue 5, Pages 956-958 (November 2016) DOI: 10.1016/j.immuni.2016.10.030 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 BTLA+ DCs Promote CD5 Expression on T Cells that Instruct Treg Cell Differentiation Antigen presentation in steady state by BTLA−CD11c+ DCs fails to upregulate CD5 expression in T cells and does not alter the subsequent immune response (left). BTLA+DEC205+CD8+CD11c+ DCs specifically mediate the upregulation of CD5 expression in T cells via HVEM engagement and instruct Treg cell differentiation (right). HVEM engagement increases phosphorylation of MEK. MEK increases the expression of the Cd5-positive regulator ETS1 and inhibits the expression of the Cd5-negative regulator TCF-3. Immunity 2016 45, 956-958DOI: (10.1016/j.immuni.2016.10.030) Copyright © 2016 Elsevier Inc. Terms and Conditions