H3K27 Demethylases, at Long Last

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H3K27 Demethylases, at Long Last Tomek Swigut, Joanna Wysocka Cell Volume 131, Issue 1, Pages 29-32 (October 2007) DOI: 10.1016/j.cell.2007.09.026 Copyright © 2007 Elsevier Inc. Terms and Conditions

Figure 1 Methylation and Demethylation of H3K27 (A) An enzymatic subunit of the Polycomb complex PRC2 called EZH2 catalyzes mono-, di-, and trimethylation of H3K27. UTX and JMJD3 are specific H3K27 di- and trimethyl demethylases. (B) UTX demethylates Hox gene promoters during the transition from a pluripotent to a differentiated state. ES, embryonic stem cell; EC, embryonic carcinoma cell. (C) JMJD3 is induced upon activation of macrophages by inflammatory stimuli. In macrophage activation, the enzyme has the capacity to resolve bivalent domains, for example at the promoter of Bmp-2, to enhance expression of target genes. Cell 2007 131, 29-32DOI: (10.1016/j.cell.2007.09.026) Copyright © 2007 Elsevier Inc. Terms and Conditions