Perioperative myocardial injury in patients receiving cardiac output-guided haemodynamic therapy: a substudy of the OPTIMISE Trial  M.A. Gillies, A.S.V.

Slides:



Advertisements
Similar presentations
Relationship between perioperative N-terminal pro-brain natriuretic peptide and maximum inotropic score in children after cardiac surgery  Yanqin Cui,
Advertisements

Randomized controlled trial comparing the McGrath videolaryngoscope with the C-MAC videolaryngoscope in intubating adult patients with potential difficult.
Mortality of emergency general surgical patients and associations with hospital structures and processes  B.A. Ozdemir, S. Sinha, A. Karthikesalingam,
Benefits and risks of epidural analgesia in cardiac surgery†
N-terminal pro B-type natriuretic peptide is an independent predictor of postoperative myocardial injury in patients undergoing major vascular surgery 
N-terminal fragment of pro-B-type natriuretic peptide is a predictor of cardiac events in high-risk patients undergoing acute hip fracture surgery  A.
Why is the surgical high-risk patient still at risk?
Intraoperative hypotension and delirium after on-pump cardiac surgery†
Type of anaesthesia and patient quality of recovery: a randomized trial comparing propofol–remifentanil total i.v. anaesthesia with desflurane anaesthesia 
D. M. Baron, H. Hochrieser, M. Posch, B. Metnitz, A. Rhodes, R. P
Frequency of surgical treatment and related hospital procedures in the UK: a national ecological study using hospital episode statistics  T.E.F. Abbott,
High concentrations of N-BNP are related to non-infectious severe SIRS associated with cardiovascular dysfunction occurring after off-pump coronary artery.
High concordance between expert anaesthetists’ actions and advice of decision support system in achieving oxygen delivery targets in high-risk surgery.
Optimizing oxygenation and intubation conditions during awake fibre-optic intubation using a high-flow nasal oxygen-delivery system  S. Badiger, M. John,
Plasma N-terminal pro-B-type natriuretic peptide as a predictor of perioperative and long-term outcome after vascular surgery  Olaf Schouten, MD, Sanne.
Preoperative abnormalities in serum sodium concentrations are associated with higher in-hospital mortality in patients undergoing major surgery  M. Cecconi,
Dexamethasone alone vs in combination with transcutaneous electrical acupoint stimulation or tropisetron for prevention of postoperative nausea and vomiting.
Perioperative statin therapy in patients at high risk for cardiovascular morbidity undergoing surgery: a review  B.A. de Waal, M.P. Buise, A.A.J. van.
N-terminal pro-B-type natriuretic peptide concentrations and long-term outcome after cardiac surgery: a prospective cohort study  B.H. Cuthbertson, B.L.
Late remote ischemic preconditioning in children undergoing cardiopulmonary bypass: A randomized controlled trial  Marcos A. Pavione, MD, Fabio Carmona,
Preoperative heart rate and myocardial injury after non-cardiac surgery: results of a predefined secondary analysis of the VISION study  T.E.F. Abbott,
Cardiac vagal dysfunction and myocardial injury after non-cardiac surgery: a planned secondary analysis of the measurement of Exercise Tolerance before.
A. Duma, C. Wagner, M. Titz, M. Maleczek, M. Hüpfl, V. B. Weihs, E
Role of N-terminal pro B-type natriuretic peptide in identifying patients at high risk for adverse outcome after emergent non-cardiac surgery  S. Farzi,
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries    British Journal of Anaesthesia 
Preoperative supplementation with fibrinogen concentrate in cardiac surgery: A randomized controlled study  A. Jeppsson, K. Waldén, C. Roman-Emanuel,
Pain after orthopaedic surgery: differences in patient reported outcomes in the United States vs internationally. An observational study from the PAIN.
M Ranucci, E Baryshnikova  British Journal of Anaesthesia 
Raised serum cardiac troponin I concentrations predict hospital mortality in intensive care unit patients†  T. Reynolds, M. Cecconi, P. Collinson, A.
Measuring quality of recovery-15 after day case surgery
Liberal transfusion strategy improves survival in perioperative but not in critically ill patients. A meta-analysis of randomised trials  E. Fominskiy,
A. A. Klein, T. Collier, J. Yeates, L. F. Miles, S. N. Fletcher, C
C. Cozowicz, J. Poeran, S.G. Memtsoudis  British Journal of Anaesthesia 
K.J. Chin  British Journal of Anaesthesia 
Safety culture and the 5 steps to safer surgery: an intervention study
A. Abdelnasser, B. Abdelhamid, A. Elsonbaty, A. Hasanin, A. Rady 
Saliva cyclic GMP increases during anaesthesia
E.K. Aasvang, M.U. Werner, H. Kehlet  British Journal of Anaesthesia 
Preoperative evaluation of patients with, or at risk of, coronary artery disease undergoing non-cardiac surgery  P.-G. Chassot, A. Delabays, D.R. Spahn 
Volume 71, Issue 6, Pages (March 2007)
Do old pharmacokinetic parameter estimates predict new data?
T. S. Walsh, T. P. Lapinlampi, P. Ramsay, M. O. K. Särkelä, K
M. A. Levin, G. W. Fischer, H. -M. Lin, P. J. McCormick, M. Krol, D. L
Differential modulation of interleukin‐6 and interleukin‐10 by diclofenac in patients undergoing major surgery  A.M. Mahdy, H.F. Galley, M.A. Abdel‐Wahed,
Clinical diagnostic tools for screening of perioperative stroke in general surgery: a systematic review  Z. Sun, Y. Yue, C.C.H. Leung, M.T.V. Chan, A.W.
N. Curry, C. Rourke, R. Davenport, S. Beer, L. Pankhurst, A. Deary, H
EuroSCORE II and N-terminal pro-B-type natriuretic peptide for risk evaluation: an observational longitudinal study in patients undergoing coronary artery.
C. J. Payne, S. C. Gibson, G. Bryce, A. G. Jardine, C. Berry, D. B
Volatile compared with total intravenous anaesthesia in patients undergoing high-risk cardiac surgery: a randomized multicentre study  G. Landoni, F.
Intensive care utilization and outcomes after high-risk surgery in Scotland: a population- based cohort study  M.A. Gillies, E.M. Harrison, R.M. Pearse,
Effectiveness of platelet inhibition on major adverse cardiac events in non-cardiac surgery after percutaneous coronary intervention: a prospective cohort.
Recovery of fibrinogen after administration of fibrinogen concentrate to patients with severe bleeding after cardiopulmonary bypass surgery  C. Solomon,
Optimizing cerebral oxygenation in anaesthetized patients with carotid artery stenosis: the influence of inspired oxygen fraction  P. Picton, S.K. Ramachandran,
Pregabalin has an opioid-sparing effect in elderly patients after cardiac surgery: a randomized placebo-controlled trial  A. Pesonen, R. Suojaranta-Ylinen,
E. -H. Lee, H. -M. Lee, C. -H. Chung, J. -H. Chin, D. -K. Choi, H. -J
Perioperative goal-directed therapy with uncalibrated pulse contour methods: impact on fluid management and postoperative outcome  F. Michard, M.T. Giglio,
Rare event research: is it worth it?
Neurological biomarkers in the perioperative period
Increase in endogenous erythropoietin synthesis through the normobaric oxygen paradox in cardiac surgery patients  Y. Ciccarella, C. Balestra, J. Valsamis,
Effect of body mass index in acute respiratory distress syndrome
Inter-hemispheric cerebral oxygen saturation differences during thoracic surgery in lateral head positioning†  T.M. Hemmerling, R. Kazan, D. Bracco  British.
S. Radhakrishna  British Journal of Anaesthesia 
Elevated serum concentrations of erythropoietin after xenon anaesthesia in cardiac surgery: secondary analysis of a randomized controlled trial  C. Stoppe,
A randomized trial of the effect of low dose epinephrine infusion in addition to tranexamic acid on blood loss during total hip arthroplasty  Ø. Jans,
Comparison of sedation and general anaesthesia for transcatheter aortic valve implantation on cerebral oxygen saturation and neurocognitive outcome†  
Fibrinogen plasma concentration before delivery is not associated with postpartum haemorrhage: a prospective observational study  O. Karlsson, A. Jeppsson,
High-sensitive cardiac troponin T measurements in prediction of non-cardiac complications after major abdominal surgery†   P.G. Noordzij, O. van Geffen,
N-terminal pro-B-type natriuretic peptide levels and early outcome after cardiac surgery: a prospective cohort study  B.H. Cuthbertson, B.L. Croal, D.
Effects of dexmedetomidine on adrenocortical function, and the cardiovascular, endocrine and inflammatory responses in post-operative patients needing.
R. Parke, S. McGuinness, R. Dixon, A. Jull 
Presentation transcript:

Perioperative myocardial injury in patients receiving cardiac output-guided haemodynamic therapy: a substudy of the OPTIMISE Trial  M.A. Gillies, A.S.V. Shah, J. Mullenheim, S. Tricklebank, T. Owen, J. Antonelli, F. Strachan, N.L. Mills, R.M. Pearse  British Journal of Anaesthesia  Volume 115, Issue 2, Pages 227-233 (August 2015) DOI: 10.1093/bja/aev137 Copyright © 2015 The Author(s) Terms and Conditions

Fig 1 Proportion of patients with serum high-sensitivity cardiac troponin I (TnI) concentrations above the 99th percentile upper reference limit (URL) before and after surgery. British Journal of Anaesthesia 2015 115, 227-233DOI: (10.1093/bja/aev137) Copyright © 2015 The Author(s) Terms and Conditions

Fig 2 Log serum TnI for each group at each time point. Data are presented as median (inter-quartile range), with outlier values represented as individual points. Log TnI=Log serum troponin I. Blue, time 0; green, time 24 h; pink, time 72 h. British Journal of Anaesthesia 2015 115, 227-233DOI: (10.1093/bja/aev137) Copyright © 2015 The Author(s) Terms and Conditions

Fig 3 Proportion of patients with serum N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations above the 97th percentile URL before and after surgery. British Journal of Anaesthesia 2015 115, 227-233DOI: (10.1093/bja/aev137) Copyright © 2015 The Author(s) Terms and Conditions

Fig 4 Log serum NT-proBNP for each group at each time point. Data are presented as median (inter-quartile range), with outlier values represented as individual points. Log NT-proBNP=Natural logarithm of serum NT-proBNP. Blue, time 0; green, time 24 h; pink, time 72 h. British Journal of Anaesthesia 2015 115, 227-233DOI: (10.1093/bja/aev137) Copyright © 2015 The Author(s) Terms and Conditions